-
Study aim
-
The evaluation of the local dexamethasone effect on reducing pain and swelling to local use into third molar socket in mandibular impacted third molar surgery on patients referred to the Special Clinic of Shiraz Dental School.
-
Design
-
Clinical trial with control group, with parallel groups, random allocation using binary block division, double blind, second phase on 30 patients, the random allocation procedure is determined by the statistical consultant.
-
Settings and conduct
-
In this study, a clinical trial is performed on the patients referred to the Special Clinic of Shiraz Dental School and the patients are 18 to 30 years old who have bilateral mesioangular impacted third molar with similar clinical and radiographic condition after obtaining informed consent, randomly enter the study.
In first tooth surgery, gelfoam impregnated with half vial of 4 gram dexamethasone Zahravi Pharmaceutical Company and in second surgery performed one week after the first surgery, gelfoam without dexamethasone is inserted into the socket of the extracted tooth and the area is sutured. 1, 3 and 10 days later, the swelling is measured with a white paper tape from the tragus to the corner of the lip and pain is measured by Visual Analog Scale Questionnaire. The patient and the person who measures pain and swelling are blinded in the study.
-
Participants/Inclusion and exclusion criteria
-
Participants: The patients with no immune system problems, with bilateral impacted mandibular third molars and age-group 18 to 30 years old.
Participants not allowed: The patients with immune system problems, infection and aphthous after surgery.
-
Intervention groups
-
Immediately after surgery on both sides, randomly one side with dexamethasone-impregnated gelfoam and the other side are placed with gelfoam without dexamethasone.
-
Main outcome variables
-
Pain and swelling are assessed 1, 3 and 10 days later.