Comparison of the effect of intravenous ondansetron and granistron with placebo on hemodynamic variables and the need for ephedrine in women candidates for cesarean section under spinal anesthesia

Comparison of the effect of intravenous ondansetron and granistron with placebo on hemodynamic variables in women candidates for cesarean section under spinal anesthesia

A clinical trial with a control group, with parallel groups, double-blind, randomized, phase 2 is performed on 60 patients. Random allocation software version 1.0 is used for randomization under Windows.

This study is performed on women candidates for cesarean section under spinal anesthesia in Kosar operating room of Shahid Sadoughi Hospital in Yazd. Prior to spinal anesthesia, the study drug or placebo is injected intravenously and then hemodynamic variables are measured and recorded during surgery and during recovery. This study is double-blind and neither the researcher nor the patient knows the type of drug prescribed, so that the drugs are prepared and coded in three identical syringes and the third person injects the drug for the patient based on the specified code.

Inclusion criteria: Pregnant women aged 20-35 years, Class I ASA, non-emergency cesarean section, spinal anesthesia Non-inclusion criteria: dissatisfaction with the study, diabetes, preeclampsia and eclampsia, severe heart, lung, kidney and liver disease, drug addiction

Intervention group1: In this group, granisetron at a dose of 3 mg equivalent to 3 ml is injected slow intravenously immediately before spinal anesthesia. Intervention group 2 : In this group, ondansetron in a dose of 4 mg in a volume of 3 ml is injected slowly into intravenous patients immediately before spinal anesthesia. Control group: In this group, 3 ml normal saline is injected slow intravenously immediately before spinal anesthesia.

Systolic blood pressure; diastolic blood pressure; mean arterial blood pressure; heart rate

In order to randomly allocate 60 eligible applicants, we randomly divide them into three groups of 20 people. For this purpose, we use Random allocation software version 1.0 under Windows to create a sequence, and by using this software we make A list which is specified from 1 to 60 with group A or B or C treatment By Using this list, we give the first person who is eligible to enter the study, number one and the last person the number 60, then based on the random allocation list and by the software, it is determined which group A or B or C each person is in. Each drug is placed in a package and the packages are coded and based on the table of random numbers and specified code, the drug is given to patients by a third person who is not involved in evaluating patients and recording results.

Patients and researchers themselves are unaware of which medication the patient has received, in this way, each drug is placed in a package and the packages are coded and based on the table of random numbers and specified code, the drug is given to patients by a third person who is not involved in evaluating patients and recording results.