comparison of the effect of Ketorolac and Betamethasone injection on post complications of third molar surgery (A clinical trial)

Comparison of the effect of preoperative betamethasone and ketorolac injection on postoperative pain, swelling and trismus

Patients requiring mandibular third molar surgery are randomly divided into 2 intervention groups with equal number, gender, and similar severity. In each group, the anesthesia process will be performed with the same protocol and using perzocaine-E. Then 1mL of betamethasone LA or 30 mg of ketorolac is injected into the master muscle. Surgery is performed by the same surgeon in a dental office using a standard procedure appropriate to the type of incision. After work, patients are given the same painkillers (acetaminophen 325mg) and antibiotics (amoxicillin 500mg and metronidazole 250mg, one every 8 hours). Outcome assessment is performed before surgery, two days and 7 days after surgery. Patients in this study are blind.

Dr nazari dental clinic

Inclusion criteria: ages of 18 and 40, physical health (ASA I or II), the presence of a third mandibular molars whose occlusion is confirmed by panoramic radiography and free of infection and pericoronitis. Exclusion criteria: Concomitant use of antibiotics and nsaid drugs, salicylates, anticoagulants, anticonvulsants, and valproate . Consumption of fines for each of these substances in the past month (drugs, alcohol, opium, smoking) A person who has smoked at least two cigarettes a day in the past month, underlying diseases that interfere with wound healing such as systemic diseases such as diabetes, hypertension, Gastrointestinal diseases, kidney and lung disease, pregnancy, and any allergies to the drugs used in this study are surgical complications that are difficult to classify according to (Pell and Gregory classification Winter classification).

1.KETOROLAC 2.BETAMETHASONE LA

PAIN ,SWELLING , TRISMUS

In the present study, the randomization block method with classification will be used. The classification will be based on gender and difficulty of surgery. Random sequencing will be performed by a statistical expert using Excel software with RANDOM function and Sort command in each class separately and codes A and B. To prevent the prediction of the last patient group in each block, blocks with different sizes of two, four and six in all classes will be used. Randomization will be considered for 40 patients in each class.

Blinding will be done on one level, only the participant. Participants will not be able to identify the type of injectable drug because they will not be informed of the drug group to which they will belong. Patients are grouped through exactly the same envelopes containing the letters A or B. The physician is aware of the relationship between the letters and the drug, but patients are unaware. Patients will be informed about the drugs used in the trial before participating in the study.