Evaluation of the sedative effect of intravenous lidocaine in patients undergoing Endoscopy with Propofol-Ketamine

Identifying the effect of intravenous lidocaine on reducing complications and unpleasant reactions in patients undergoing endoscopy with propofol-ketamine including pain reduction, reduction of nausea and vomiting, reduction of apnea frequency and hemodynamic instability, and reduction of length of stay in recovery

The clinical trial with control group, double blind,Parallel group,randomised, phase 3 on 138 patients, patients with simple randomization of quadruple permutation block will be divided into two groups of intervention and control that the intervention group will receive Propofol, Ketamine and intravenous Lidocaine and the control group will receive Propofol and Ketamine.

Outpatient endoscopic candidates referred to the ahvaz imam khomeini hospital will be divided into intervention and control groups.The present study is double-blind so that patients and physicians will be unaware of the allocation of the control group and the intervention group.

patients between 18 to 65 years age who are candidates for endoscopy that classified as group 1 and 2 according to the American Society of Anesthesiology (ASA Class) and who do not have severe heart or lung disease, kidney or liver failure, and allergies to Propofol, Ketamine, or Lidocaine will be included in this study.

Intervention group:receives 0.5 mg per kg of Propofol, 0.5 mg per kg of Ketamine and 1.5 mg per kg of intravenous Lidocaine Control group:receives 0.5 mg per kg of Propofol and 0.5 mg per kg of Ketamine

Sedation level, Hemodynamic instability, drug use level

By easy sampling method, the patients who are eligible to enter the study are randomly divided into two groups of intervention and control. In this study, the individuals are divided into four quadratic block methods.A Is the person receiving the intervention, and B represents the person in the control group.Considering the quadruple block, instead of AABB code 0, instead of ABAB code 1, give ABBA code 2, BAAB code 3, BBAA code 4 and BABA code 5 to 9. Then, using the table of random numbers, we randomly select the starting point and then consider 21 numbers as rows or columns. Whatever number we encounter, we replace the corresponding permutation.Finally, by selecting 21 items from the table, a total of 138 people will be divided into two groups

After selecting the samples, the study participants, the endoscopist, and the principal investigator are unaware of the allocation, and the drugs are injected by an anesthesiologist who is aware of the allocation, and the data are collected by them