Evaluating the effects of hyaluronic acid mucoadhesive films with two different concentrations on palatal epithelial wound healing and post-operative discomforts after free gingival graft surgery

To determine the effects of hyaluronic acid (HA) mucoadhesive films with two different concentrations on palatal epithelial wound healing and post-operative discomforts after free gingival graft (FGG) surgery

Clinical trials with a control group, with parallel groups, double-blind, randomized. Patients will randomly divided into three groups using the option of generating random numbers in https://kitset.ir.

Patients selected from candidates for FGG surgery referred to the periodontology department of Babol University of Medical Sciences in 1401.

Inclusion criteria: 1. Patients over the age of 18; 2. Patients who required free gingival graft; 3. Presence of sufficient donor tissue dimensions in the palate (length: 10-15mm, width: 5-8mm, thickness: 1-1.5mm); Exclusion criteria: 1. Systemic diseases and conditions affecting wound healing (such as uncontrolled diabetes, autoimmune diseases, history of alcoholism); 2. Presence of attachment loss (greater than 3mm) in the palatal area of premolars and first maxillary molars; 3. Use of corticosteroids; 4. Use of antibiotics in the past month; 5. Pregnancy or breastfeeding; 6. Smoking.

Giving sufficient information, taking informed consent, Phase I periodontal therapy, Harvesting free gingival graft, Placing mucoadhesive films containing 0.8% HA (test group1), mucoadhesive films containing 0.2% HA (test group2) and HA free biofilms (control group) in the donor site, stabilizing it by sutures, Covering it with periodontal dressing, Regular evaluation on days 3, 7, 14, 21 and 42 after surgery.

If the results are statistically significant, using mucoadhesive biofilms containing HA could be considered as an adjunctive way for accelerating palatal epithelial wound healing and reducing post-operative discomforts of FGG surgery.

In order to randomly grouping the participants, we will use the option of generating random numbers in https://kitset.ir. Then, according to the random numbers, the first 13 numbers are in the first group, the next 13 numbers are in the second group, and the last 13 numbers are in the third group. Finally, the labeled biofilms (by the pharmacologist) are used in individuals of the all three groups.

The biofilms containing hyaluronic acid with two different concentrations and the biofilms without hyaluronic acid are labeled with numbers by the pharmacologist and provided for the operator. The operator will be unaware of the type of biofilm used in the patient.