Evaluation of the effect of aspirin consumption on permanent Internal Jugular dialysis catheter patency in End Stage Renal Disease (ESRD) patients

The effect of aspirin consumption on permanent internal jugular catheter patency in patients with End Stage Renal Disease (ESRD) referred to Bahman Hospital and Shafa center for dialysis in Zanjan city

Clinical trial with control and intervention groups, one side blind, randomized, phase 3 on 84 patients. Spss 26 software was used for randomization.

84 dialysis patients with permanent internal jugular catheter referred to Bahman Hospital and Shafa Dialysis Center in Zanjan are included in the study and randomly divided into two control and intervention groups. The first group is given placebo and the second group is given aspirin daily for 6 months along with dialysis treatment. The required information is recorded based on the patients' files. In the end, by analyzing the data, the effect of aspirin on the survival time of the catheter is determined.

entry conditions : 1)the patient has ESRD 2)at least one month should be passed since the start of hemodialysis maintenance 3)at least one month & at most one year should be passed since the installation of the internal jugular permcath 4)there should'nt have any contraindication for normal use of Aspirin No entry conditions: 1)current Aspirin use at the time of entry in the study 2)the presence of known underlying diseases that increase the risk of thrombosis 3)use of anticoagulants 4) use of Tarulac 5)catheter infection before onset of study 6)imperfection of the patient`s file regarding the items required 7)patient disfavor to enter the study

In the intervention group, aspirin 80 mg and in the control group, placebo is given to the patients daily for 6 months, and the survival time of the catheter is recorded in both groups.

Survival time of permanent internal jugular dialysis catheter

The samples will be randomly assigned to one of the two control and intervention groups, which will use Excell 2016 edition for randomization. To do this, we enter 42 numbers 1 and 42 numbers 2 in the first column. Then in the second column we use the RAND () function and generate 84 random numbers. We arrange the data based on, column including values of random numbers (ascending or descending). With this sorting, the order of numbers 1 and 2 in the first column will also change and be placed randomly. Based on the order of appearance of numbers 1 or 2 and according to the list of names of people included in the study, the samples are assigned to 2 groups.

The main researchers and data analysts will know which group each of the samples are in, but the samples themselves will be told that the drug given to them is aspirin, and the side effects of aspirin will be explained to the patients and consent Admission to the study is taken. Therefore, the samples will not know which control or intervention group they are in. The main researchers are responsible for data collection, and in this study, the only communication will be between the main researchers and the patients, and other than the person responsible for data analysis, no other people will have a role in this study.