Comparison of two quadruple regimens of amoxicillin, bismuth, levofloxacin and pantoprazole versus amoxicillin, clarithromycin, bismuth, pantoprazole to eradicate Helicobacter pylori

Comparison of two quadruple diets of amoxicillin, bismuth, levofloxacin and pantoprazole versus amoxicillin, clarithromycin, bismuth, pantoprazole to eradicate Helicobacter pylori

Clinical trial with control group, with parallel groups, double-blind, randomized, phase 3 on 196 patients. Software Random Allocation software will be used for randomization

This study is an interventional study and the study population is patients infected with Helicobacter pylori referred to a private clinic in Rasht. Patients who go to the clinic with a complaint of dyspepsia, reflux and meet the inclusion criteria will be admitted to the study after confirmation of consent. patients will be randomly divided into 88 groups. The first group will be treated with clarithromycin, pantoprazole, bismuth tablets , and amoxicillin. The second group will receive a treatment regimen containing levofloxacin , pantoprazole, bismuth tablets and amoxicillin. Patients who have completed treatment will have another urease breath test to check for eradication of Helicobacter pylori 4 weeks after the end of treatment.

Inclusion criteria: all patients with positive Helicobacter pylori test after endoscopy. Exclusion criteria: dissatisfaction with continued cooperation, drug sensitivity and severe side effects of contraindications to levofloxacin

the intervention group will use a four-drug regimen containing levofloxacin 500 daily, pantoprazole 20 twice daily, bismuth tablets every 12 hours, and amoxicillin 1 g every 12 hours. the control group of the usual four-drug treatment group underwent clarithromycin 500 twice daily, pantoprazole 20 twice daily, bismuth tablets every 12 hours and amoxicillin 1 g every 12 hours.

Eradication of Helicobacter pylori

The randomization method is 49 quadruple blocks in random blocks. The randomization method is 49 quadruple blocks in random blocks. After adopting the sequence list of blocks, this list is enclosed in a locked envelope and sealed in the clinic nursing center Digestive research is maintained and read daily after the start of the study, and patients with inclusion criteria will receive their medication regimens according to the list.

This study is of Open Lable type, because patients' medications are specific and have different colors and sizes. However, the researcher does not know the type of medication patients receive.