Evaluation of the effect of adding Trimetazidine to standard treatment of patients with Aluminum phosphide poisoning,referal to Loghman Hospital In Tehran، a pilot study on mortality

Determining the effect of adding Trimetazidine to standard treatment of Aluminum phosphide poisoning

Clinical trial of control group drug with parallel, single-blind, randomized groups

In this study,30 patients who were diagnosed with Aluminum phosphide poisoning and referred to Loghman poisoning center were included and were randomly divided into two groups of 15 by random allocation software . All patients were in the age group of 18-60 years who were poisoned with oral form and arrived at the emergency part of Loghman Hospital 24 hours before consuming rice pills. Inclusion criteria in addition to age group and time and history Taking rice aluminum phosohide and clinical signs ,silver nitrate test Positive or negative or silver nitrate test is positive in the absence of the above clinical symptoms or in the absence of clinical symptoms, their carbon monoxide test is higher than 10 if not smoking.

Inclusion Criteria: 1-Poisoning with oral form of Aluminum Phosphide tablets and referring to medical centers before 24 hours 2- Age range 18 to 60 years 3-Clinical signs based on phosphide aluminum tablet poisoning 4-Positive silver nitrate test of oral and gastric secretions 5-Carbon monoxide levels above 10 in non-smokers Exclusion Criteria: 1-Renal glomerular filtration rate less than 30 on arrival 2-Known heart failure and a history of acute myocardial infarction 3-Pregnant and lactating women 4- Concomitant use of drugs such as methadone, tricyclic antidepressants and amphetamines

Patients with Aluminum phosphide poisoning are divided into two groups of 15 people with standard treatment +Trimetazidine group and standard treatment group.

Hospital mortality, need for ICU, intubation,

In this research, block random sampling method will be used. In the present study, 2 groups are studied (intervention group and control group) Therefore, quadruple blocks will be used. According to the calculated sample size (total number of 30 people who are divided into two groups of 15 people). 8 quadruple blocks will be considered. Random assignment of individuals to the groups under study will be done in this way. First, 15 envelopes containing four cards with A, B, C, D Latin letters were prepared, letters A and B = intervention group, letters C and D = as control group. According to the inclusion criteria, they were asked to The 30 sealed envelopes randomly selected one and randomly selected a card from within that the card label determined the assignment of the individual to each of the two study groups.

In this study, patients are unaware of the drug allocation, in fact, the patient does not know whether he is receiving Trimetazidine in addition to standard treatment or only under standard treatment. Before starting the drug. Explain to each patient or their first-degree family Will be given to enter a clinical trial study with written consent and informed consent. The nurses responsible for administering the medication are in the process of designing the study but are unaware of the interventions and objectives under study but Internal medicine specialists, toxicologists and cardiologists are aware of this issue.

The results of the study will be published as a scientific article

Access will be available after the article is published

Reputable scientific and research centers

For further studies

By email to the person in charge of the research project

No specific process is considered