Evaluation of the efficacy of conditioned medium derived from human umbilical cord Wharton jelly mesenchymal stem cells in comparison with intralesional triamcinolone in the treatment of alopecia areata

Evaluation of the efficacy of conditioned medium derived from human umbilical cord Wharton jelly mesenchymal stem cells in comparison with intralesional triamcinolone in the treatment of alopecia areata

This phase 1 study is performed on 28 patients with hair loss. In group A, 6 sessions were given to each patient at intervals of 2 weeks and in each session, medium conditioning was injected (intervention) and in group B, triamcinolone was injected to patient for three sessions at intervals of one month per session (control). ). All patients before the treatment and 2 months after the second visit and photos are taken by digital camera and tricoscan.

This project is carried out in the Skin and Stem Cell Research Center of Tehran University of Medical Sciences. In group A, 6 sessions were given for each patient at 2-week intervals and in each session, medium conditioning was injected, and in group B, triamcinolone was injected for 3 sessions per patient at one-month intervals.

Inclusion criteria: men and women with alopecia areata, age 18 years and older and less than 50 years, complete patient consent to participate in the project. Exclusion criteria: platelet disorders, thrombocytopenia, patients receiving anticoagulants, patients with malignancy, receiving chemotherapy in the last 5 years, patients with sepsis, smoking, pregnancy, ulcers or active infections at the treatment site.

In group A, 6 sessions were given for each patient at 2-week intervals and in each session, medium conditioning was injected (intervention), and in group B, triamcinolone was injected for 3 sessions per patient at one-month intervals (control).

The amount of hair loss; side effects; patient's satisfaction; tolerability

Each patient is randomly divided into one of two groups A or B: in group A for each patient 6 sessions at intervals of 2 weeks and in each session medium conditioning is injected and in group B for patient 3 sessions with an interval of 1 month Triamcinolone is injected. The outcome assessor and the blind data analyzer will be considered.