Investigating the effect of blackberry syrup on reducing hypertrophy of tonsils and its clinical symptoms in patients aged 5 to 15 years

Explaining tonsil enlargement in Persian medicine and study the effect of blackberry paste on tonsil hypertrophy

The clinical trial is two-blind and random. The random assignment of patients to intervention and control is done by the method of quadruple random blocks and by a statistical consultant. 72 envelopes are prepared and in each envelope, the letter A or B is placed and will be numbered from 1 to 72. The letter A will belong to the intervention group and the letter B will belong to the control group. The sample size in each group is 36 people and in total 72 people.

Clinical trials in the field of traditional medicine will be performed in patients of Toobi Clinic in Sari and Bouali Specialized Clinic in Sari. Random assignment of patients to intervention and control is done by a statistician who does not have access to patients. There is no medicine or placebo inside.

Conditions for patients with tonsillar hypertrophy older than 5 years and younger than 15 years who want to participate in this project and use traditional medicine products. Withdrawal conditions include acute tonsillitis, tonsillar abscess, unstable clinical condition, systemic corticosteroid use or antibiotics from 4 weeks ago, allergy to blackberry and honey, symptoms of incompatibility with consumption of blackberry product, inability to communicate and unwillingness of the patient to Continuation of cooperation in the study

Includes intervention and control groups. In the intervention group, patients were given blackberry oral syrup for 4 weeks and the control group was given placebo for 4 weeks.

Tonsil size, Dysphagia, nasal speech, mouth breathing during sleep, snoring at night before and 4 weeks after intervention; Tonsillectomy was performed 4 and 12 weeks after the intervention

In this study, random assignment of patients to experimental and control groups will be done using the quadruple random blocks method. We know that the number of possible blocks of four of the two letters A and B is equal to 6; As follows: (AABB-ABAB-ABBA-BAAB-BABA-BBAA) If we denote them by the numbers 1 to 6, to randomly assign them using blocks of 4, first by throwing 18 regular hexagons, a random sequence of numbers 1 to 6 into 18 blocks of 4 from the sub-generated blocks Will: In the desired sequence, there will be 36 letters from each letter A and B. According to the above blocks, 72 envelopes will be prepared and in each envelope, the letter A or B will be placed and will be numbered from 1 to 72. The person delivering the envelopes to the patients does not know what is inside. The production of a random sequence is done by a statistics and methodology consultant who does not have access to patients and only he knows what is in each issue. Patients who received the letter A will be in the intervention group and patients who received the letter B will be in the control group.

Patients with tonsillar hypertrophy are randomly divided into intervention and placebo groups according to the inclusion criteria. After random sampling and determining whether the patient belongs to the intervention or control group, it is justified by the clinical caregiver and The required training is provided and the package containing the guide and medication brochure will be delivered to patients. In addition to oral explanations about how to study, how to use the drug, the amount and time of use and frequency and duration of treatment are explained. Intervention and control groups will be performed using the quadruple random blocks method. According to the above blocks, 72 envelopes will be prepared and in each envelope, the letter A or B will be placed and will be numbered from 1 to 72. The person delivering the envelopes to the patients does not know what is inside. The production of a random sequence is done only by a "statistics and methodology consultant" who does not have access to patients and only he knows what is in each issue. Patients who received the letter A in the intervention group and patients who received the letter B. All patients will not be aware of the type of drug in the package, including one of the placebo or the main drug under study.