Comparative study Intraoperative methadone and morphin for postoperative pain after rhinoseptoplasty

Determining and comparing the effect of methadone and morphine on pain after rhinoseptoplasty surgery

In the main and studied group, the desired dose of the drug is 0.15 mg per body weight (ideal weight). Methadone is administered slowly intravenously half an hour after the start of surgery. In the study group, the desired dose of the drug was 0.15 mg per body weight (ideal weight). Morphine is administered slowly intravenously half an hour after surgery.

This study is conducted in a double-blind manner, that is, patients, doctors, caregivers, and statistical analysts will not know about the allocation of groups to reduce bias. . During the operation, hemodynamic variables were recorded and recorded with the results. We compare the results of the control group. In case and control groups, follow-up, study and recording of variables identified at the end of surgery and patient extubation and recovery and 1 and 6 hours after surgery by the researcher include: variables such as nausea and vomiting and bleeding, the amount of analgesic and sedative use, headache and severity Postoperative pain (according to the VAS table) and using the pain observation scale, the frequency of headache, postoperative nausea and vomiting and the amount of analgesia used 6 hours after surgery will be evaluated and then compared.

Candidate patients for rhinoplasty surgery ECG normal and (no long QT)

In the main and studied group, the desired dose of the drug is 0.15 mg per body weight (ideal weight). Methadone is administered slowly intravenously half an hour after the start of surgery.

Intensity of pain/ Hemodynamics

Randomization is performed using random block allocation with 4 blocks, which have all four modes A, A, B, B, AA B, B B A A and B A A B A, A B B A, B A A A B, written in 6 cards and The first four patients are randomly grouped. The ward manager takes the patient card out of the bag and the patients are divided into groups by lot. For example, if lottery a A b b The first and second patients are in the first group and the third and fourth patients are in the second group and also for the next four patients, a card is issued again. The anesthesia and injection stage will be performed by an anesthesiologist and The questionnaire is reviewed and completed by an anesthesiologist in the operating room and recovery. Describe how to blind

This study is conducted in a double-blind manner, that is, patients, doctors, caregivers, and statistical analysts will not know about the allocation of groups to reduce bias. In these studies, random assignment is used to allocate patients into two groups: the experimental group and the control group. Researchers and participants are made aware of who is in which group. The study will be conducted in a way that the surgeon, nurses, patients, and the data analyst will not know the type of painkillers injected into the control and intervention groups. Statistical analyst will be selected from outside the treatment team to ensure double-blindness of the study to a large extent. When the patient is not aware of the type of medicine received, the effect of the patient's personal characteristics and psychological aspect on the research results is reduced. Researchers are unaware of which type of painkillers the participant receives. Therefore, the impact of the doctor's judgments in evaluating the clinical symptoms and the patient's pain after surgery is minimized. By using this method, we try to reduce the effect of possible biases in the results (the effect of methadone and morphine in reducing pain).

It can be published as much as possible

Access period starts 6 months after the results are published

Researchers working in academic and scientific institutions

Results only

Dr. Daman Pak Forqani Hospital

Using the email educationmo110@gmail.com