Objective: One-stage oral disinfection quickly delete or reduce all oro-pharyngeal pathogens. The purpose of the present study is to evaluate the effect of one stage full mouth disinfection on serum IL17 and IL23 levels in patients with moderate to severe chronic periodontitis. METHODS: 33 patients with moderate to severe chronic periodontitis in terms of medical health and without history of taking medication were randomly selected. Blood samples were taken before treatment. Scaling and root planning, tongue disinfection, mouth washing and sub- gingival irrigation was performed. The second blood sample was obtained two weeks after treatment. Serum levels of IL-17, 23 were obtained using ELISA method.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT201103165900N3
Registration date:2011-04-14, 1390/01/25
Registration timing:retrospective
Last update:
Update count:0
Registration date
2011-04-14, 1390/01/25
Registrant information
Name
Ali Zarandi
Name of organization / entity
Hamedan dental faculty
Country
Iran (Islamic Republic of)
Phone
+98 81 1825 0498
Email address
zarandi.ali@umsha.ac.ir
Recruitment status
Recruitment complete
Funding source
Hamedan university of medical sciences and health services
Expected recruitment start date
2010-12-06, 1389/09/15
Expected recruitment end date
2011-03-06, 1389/12/15
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Evaluation the effect of one stage full mouth disinfection on serum IL17 and IL23 levels in patients with moderate to severe chronic periodontitis
Public title
Evaluation the effect of one stage full mouth disinfection on serum IL17 and IL23 levels in patients with moderate to severe chronic periodontitis
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
1- patients aged 25 to 70 years
2- Having at least 12 teeth (regardless of third molars, teeth with orthodontic appliances, crowns, bridges and implants)
3- Diagnosis of moderate to advanced chronic periodontitis
4- having informed consent.
Exclusion criteria:
1- Patients with a contra-indication for surgery or local anesthesia or scaling
2- Systemic disease (eg diabetes mellitus, cancer, AIDS, metabolic bone disease, diseases that delay the healing pockets, previous radiotherapy or immunosuppressive treatment, autoimmune diseases, allergies, infectious diseases, neutropenia, bleeding disorders, Rheumatoid arthritis, bowel disease, lung disease, multiple sclerosis)
3- pregnancy or lactation
4- History of systemic antibiotics use in the past six months
5- History of continuous use of NSAIDS in the past six months
6- scaling and root planning in the past year
7- contagious diseases
8- History of smoking in the past six months
Age
From 25 years old to 70 years old
Gender
Both
Phase
3
Groups that have been masked
No information
Sample size
Target sample size:
33
Randomization (investigator's opinion)
N/A
Randomization description
Blinding (investigator's opinion)
Single blinded
Blinding description
Placebo
Not used
Assignment
Other
Other design features
It is a before & after study without any control group.
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Ethics committee of Hamedan university of medical sciences and health services
Street address
Vice chancellor for research, Hamedan University of Medical Sciences and Health Services, Fahmideh Street
City
Hamedan
Postal code
518/65178
Approval date
2010-12-06, 1389/09/15
Ethics committee reference number
137619/9/35/16/پ
Health conditions studied
1
Description of health condition studied
periodontitis
ICD-10 code
K05.3
ICD-10 code description
Chronic periodontitis
Primary outcomes
1
Description
serum levels of IL-17
Timepoint
6 weeks later
Method of measurement
laboratory assessment (IL-17 ELISA kit)
Secondary outcomes
1
Description
serum IL-23 level
Timepoint
6 weeks later
Method of measurement
laboratory assessment (IL-23 ELISA kit)
Intervention groups
1
Description
one-stage full mouth disinfection
Category
Treatment - Other
Recruitment centers
1
Recruitment center
Name of recruitment center
Hamedan dental faculty
Full name of responsible person
Ali Zarandi
Street address
City
Hamedan
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Hamedan dental faculty
Full name of responsible person
Ali Zarandi
Street address
Periodontics department, Hamedan dental faculty
City
Hamedan
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Hamedan dental faculty
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Hamedan dental faculty
Full name of responsible person
Ali Zarandi
Position
Periodontics post-graduate student
Other areas of specialty/work
Street address
Periodontics department, Hamedan dental faculty
City
Hamedan
Postal code
Phone
+98 81 1825 0498
Fax
Email
zarandi.ali@umsha.ac.ir
Web page address
Person responsible for scientific inquiries
Contact
Name of organization / entity
Hamedan dental faculty
Full name of responsible person
Ali Zarandi
Position
Periodontics post-graduate student
Other areas of specialty/work
Street address
Periodontics Department, Hamedan dental faculty
City
Hamedan
Postal code
Phone
+98 81 1825 0498
Fax
Email
zarandi.ali@umsha.ac.ir
Web page address
Person responsible for updating data
Contact
Name of organization / entity
Hamedan dental faculty
Full name of responsible person
Ali Zarandi
Position
Other areas of specialty/work
Street address
City
Postal code
Phone
Fax
Email
Web page address
Sharing plan
Deidentified Individual Participant Data Set (IPD)