A comparative investigation of therapeutic effect ND yag laser on small vascular lesions on the lower limbs with energy of 160-180 and pulse duration of 50 with respect to energy 120-140 and pulse duration 10

Using the results of this study, we can help treat lower limb vascular lesions with ND yag laser.

A clinical trial with a control group, with parallel groups, double-blind (patient, analyzer and evaluator) as a computer block randomized by SPSS software and phase 2 is performed on 37 patients. In this way, if both lower limbs are involved, one limb is randomly lasered with an energy of 160-180 and a pulse of 50 and the other limb with an energy of 120-140 and a pulse of 10. But if only one limb is involved, based on the medial and lateral of that limb, the mentioned energy and pulse are given randomly.

The first session is patient selection and sono Doppler and then the first laser session(Randomly energy 120-140 and pulse 10 versus energy 160-180 and pulse 50) Second session (2 months later) Evaluate the response and perform the second laser session(same energy and pulse of their first session) Third session (2 months later second session) Final evaluation(Based on response to treatment) Location: Razi Hospital Laser Clinic Double-blind RCT (patient, statistical analyzer, assessor)

37patients Inclusion: Having a vascular lesions both above and below the knee; signing an inform consent; vascular lesions smaller than 3 mm. Exclusion: Having a history of arterial and venous thrombosis; active infection on the area of laser; history of liver cirrhosis or consumption of ocp; vascular lesion only on one side of the knee; history of laser or sclerotherapy during the past 6 months; Pregnancy; skin types 5 and 6; history of sunburn; lactation.

Patients with small vascular lesions of lower limb referred to the laser clinic of Razi Hospital in Tehran 1400-1401

Age; sex; family history; skin type; location; size

Randomization method: Blocks 4, 6 and 8, in which there are equal numbers of each group in each block, are used to create a balance in the number of assigned samples of each of the studied groups. Randomization unit: Cluster. For this purpose, people are clustered in groups, then sampled from clusters, and it is used when it is possible to select a group of people and it is easier than selecting people in one The community is defined. We do not have random layering. Randomization tool: statistical software SAS(Statistical Analysis System) Random allocation concealment prevents the disclosure of a random sequence so that the assigned group is not specified prior to the individual allocation. This study is two-blind (patient, assessor, statistical analyzer).

ِDouble blind: Participant, Data analyzer, Assessor The participant will not be informed of the result of the assessor and statistical analyzer during the study. The analyzer does not know how to divide the two groups and the type of treatment. The assessor does not know how to divide the two groups and the type of treatment.

All patient information can be shared without mentioning the name.

From 6 months after the end of the study until forever

Researchers, experts in the field of laser industry and Dermatologists

For scientific studies and therapeutic applications

medical University Tehran

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