Evaluation of the effect of combined herbal mouthwash (containing Thymus, Myrtus, Glycyrrhiza and Aloe Vera) on postoperation complications of mandibular impacted third molar; A randomized triple-blind clinical trial study

Evaluation of the effect of combined herbal mouthwash (containing Thymus, Myrtus, Glycyrrhiza, and Aloe Vera) on post-operation complications of mandibular impacted third molar

A triple blinded clinical trial with a control group, with parallel groups, randomized by a random table of numbers, phase 3, on 60 patients in two groups of 30.

Patients come to Qazvin Dental School at their appointment, and after the surgery, they use their respective coded mouthwash, which the patient, the examiner, and the statistical consultant don't know about its contents. After the surgery, the patients are asked to use 10 ml of the contents of their coded container, which contains herbal combined mouthwash or placebo, for 30 sec. and continue twice a day for 2 weeks. And on the 3, 7, and 14 days, refer to us for follow-up.

In this study, patients in the age range of 20-60 who needed mandibular 3rd molar surgery with the same difficult conditions are selected. After providing explanations of the method of implementation and the purpose, eligible patients with full personal consent enter the study. Inclusion criteria: Willingness and satisfaction of the patient to participate The presence of unilateral or bilateral mandibular 3rd molar Possessing a panoramic radiograph photo prepared in the last 6 months Absence of any systemic disease Not taking medicine, smoking, alcohol, and drugs Absence of pregnancy and breastfeeding Exclusion criteria: Lack of proper patient cooperation Patient's lack of satisfaction to continue the study Getting a specific disease Occurrence of pregnancy Occurrence of complications during surgery

Intervention group: recipient of herbal mouthwash (hymus, Myrtus, Glycyrrhiza, and Aloe Vera) Control group: receiving placebo (normal saline)

Swelling Trismus Pain

Simple individual randomization, by the table of random numbers: Tables of random numbers are prepared by computers that arrange numbers randomly in both row and column directions. For use, the researcher must first determine the exact number of people in the study Then, to select the sample people from the table, he randomly starts from a point of the table in the direction of the row or column, and he can choose the point by closing his eyes and placing his finger or the tip of the pen on the table. This work should continue until the number of sample people can be selected.

In this study, the patient, examiner or clinical caregiver and statistical consultant are blind to the study groups. Blinding is done by assigning codes A and B to two groups and equating the shape of the mouthwash bottle and its content.

Only part of the non-confidential data of the participants will be used and published for research purposes only. For example: age, gender, BMI, etc.

After the end of the study and the publication of the articles derived from it.

All researchers, students and related people in academic institutions

The use of data by mentioning the authors' information and referencing is free.

Correspond author: Muhammad Reza Asgari Ghonche Phone number: 09912069209 Email: m.asgari77@yahoo.com

Requests for documentation will be answered as soon as possible, within several days.