The effect of preoperative Pentoxifylline administration on postoperative pain inpatients undergoing Laminectomy

Efficacy of Pentoxifylline in pain assessment after Laminectomy surgery

The clinical trial with the control group, with parallel, double-blind, randomized, phase-referred groups, on 72 patients.www.randomization.com site is used for randomization.

In 1401, 72 patients will be included in the study in Shah Vali hospita haspital, the study will be double-blind, and the Pain Assessor and patient will be unaware of the grouping of patients. To blind the patients, placebo and for blinding the evaluator, the group encoding will be used in the form of a and b. One hour before surgery, one hour and 24 hours after surgery, pain levels will be evaluated in both groups using VAS. The reported pain is compared between the two groups and then compared.

Entry requirements: Patients who are candidates for Laminectomy surgery and are over 15 years old Non-entry requirements: Patients with alcohol or substance abuse, patients who smoked, pregnant mothers, those with liver disease, diabetes, immunodeficiency (the use of immunosuppressive drugs or chemotherapy), AIDS, acute bowel disease, cancer, Children under the age of 15 and people older than 75 who are getting information from them are difficult.

Intervention group ": In this group, one capsule of pentoxylline supplied by Farabi Pharmaceutical Company is given to the patient one hour before laminectomy. "Control Group": In this group, one hour before laminectomy, a 400 mg capsule of pentoxylline whose contents are emptied and filled with starch is given to the patient.

The rate of pain based on the VAS

Patients were randomly assigned to two groups by simple randomization method they are divided. How to select people and place them in dual groups It will be random, so after confirming the necessary conditions for the direction of Entering the study selected patients consecutively, the first patient in The first group will put the second patient in the second group. And so on. Again, the groups will take each patient to the limit. The number of samples in the intervention and control groups is equal.

Drugs studied by a neurosurger who does not have participated in the scheme , is prepared and in closed envelopes with the patient's code written on it Envelopes are preserved in the neurosurgical ward one day before surgery ; Day of surgery;The day after surgery by neurosurgeve that type of medication and The group where the patient is located does not know it opens. Nurses Patients and pain assessors are also unaware of the type of drug and the patient group.

Demographic data and results of the research

After the final report (2023)

It will be available to researchers working in academic and scientific institutions.

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