Evaluation and Comparison of the Effectiveness of General Anesthesia with Souffleran and Propofol on Nausea, Vomiting and Agitation after Bone Marrow Aspiration and Intrathecal Injection in Children with Cancer Referred to Bahrami Hospital.

Comparison of the Effect of General Anesthesia with Souffleran and Propofol on Nausea, Vomiting and Postoperative Agitation

Phase 3 clinical trial with two Arm Parallel Group with 30 Patients , Triple Blind ,Randomised trial with Sampling Table

All Participants in the Operating Room of Bahrami Hospital Will Receive 35mg / kg of Fentanyl Before Induction of Anesthesia. In the Next Stage, the First Group Will Receive Induction of Anesthesia with 8% Sulfoflurane and the Second Group with 2 mg / kg Propofol. It should be Noted that the Continuation of Anesthesia in Both Groups will be Using Isoflurane Inhalation Gas. In the Studies, Vital Signs were Measured Once Before the Treatment and then every 5 Minutes During the Duration of the Anesthesia will be Registered. After Transferring Patients to the Recovery Room, the Amount of Post-Operative Nausea and Vomiting as well as the Recovery Time will be Masured and Recorded. After the Treatment Process, the Severity of Nausea and Vomiting, Agitation , Severity of Pain and Granistron Prescription will be Registered. The Forthcoming Study will be in the form of Triple Blind.

Inclusion criteria :children Between 1 and 10 Years Old With Cancer Exclusion criteria: • Dissatisfaction • Lack of Proper Cooperation •History of Any Disease( Cardiovascular, Respiratory , Allergies)

(1) Induction Group of Anesthesia Using Soufflore and (2) Group of Induction of Anesthesia with Use of Propofol.

Mean Arterial Pressure Heart Rate Severity of Nausea and Vomiting Agitation Rate Postoperative Pain

Randomization will be done using limited randomization method of block randomization type. The size of all the blocks is equal and in this two-group trial, the participants are assigned equally to two intervention and control groups of 15 people using blocks of 6. The randomization tool will be a random sequence generation software. In order to hide random allocation, non-transparent sealed envelopes with random sequence will be used. Each of the random sequences created is recorded on a card and the cards are placed in the envelopes in order. In order to maintain the random sequence, the outer surface of the envelopes is numbered in the same order.Finally, the lids of the envelopes are glued and placed in a box. At the time of the registration of the participants, according to the order of entry of the eligible participants into the study, one of the envelopes will be opened and the assigned group of that participant will be revealed. The person who created the random sequence will not be involved in other stages of the study, including the allocation of participants.

Blinding of the Type of Intervention Performed in Patients Will Be Done in the Data Collection Stage (lack of knowledge of the Examiner about the Intervention Group) and the Stage of Data Analysis (lack of knowledge of the Statistical Analyst of the Type of Intervention in Each Group). Therefore, the forthcoming Study will be in the form of Triple Blind .In this Way, the Patients are Children and their Parents Do Not know about the Study Group and do not know Which Group they are in. On the other hand, the Person who Collects the Information and Registers it in the Patient Information Sheet does not know the Patient Group, and on the third hand, the Person who Analyzes the Information also does not know the Patient Group because the Patients are Divided into 2 Groups: 1 and 2 and do not know the Name of the Group.