Comparison of The Efficacy And Side Effects of Combined Doses of Dexmedetomidine And Propofol With Isoflurane And Nitrosoxide as a General Anesthetic Preservative in Orthopedic Surgeries

Comparison of the efficacy and side effects of combined doses of dexmedetomidine and propofol with isoflurane and nitrosoxide as a general anesthetic preservative in orthopedic surgeries

Clinical trialwithcontrolgroup,withparallelgroups,doubleblind,randomized,phase 3 on 90 patients. For randomization using a table of random numbers are assigned to three groups A, B and C (30 people in each group). The anesthesia assistant will not know the study groups and the dose of IV and inhaled drugs. The drugs will be prepared by an anesthesiologist using labels A, B and C.

This study is a randomized clinical trial to compare the efficacy and side effectsofcombineddosesofdexmedetomidineandpropofolwithisofluraneandnitrosoxide as a general anesthetic in orthopedic surgery in patients admitted to medical centers affiliated to the University of Medical Sciences. Mazandaran will be done in 1401. The research environment is the operating room of Imam Khomeini Educational and Medical Center in Sari. The study population consists of patients who are candidates for non-emergency orthopedic surgery under general anesthesia

Inclusion criteria: Age between 18-60 years, Class 1 and 2 anesthesia (ASA), Patients with complications such as hypotension, hypertension, bradycardia, pneumothorax, air embolism and decreased arterial oxygen saturation, which are possible side effects of anesthetics. , Do not have. Withdrawal conditions: Emergency surgery, known allergy to the drugs used in

Patients undergoing intravenous anesthesia using the minimum combined doseofpropofolanddexmedetomidinePatientsundergoingintravenousanesthesia using the maximum combined dose of propofol and dexmedetomidine Patients will undergo inhalation anesthesia using isoflurane and nitrous oxide.

Time to wake up from anesthesia

Patients who meet the inclusion criteria are randomly assigned (using a table of random numbers) to three groups A, B and C (30 people in each group). The anesthesia assistant will not know the study groups and the dose of IV and inhaled drugs. The drugs will be prepared by an anesthesiologist using labels A, B and C. They will be provided to the anesthesia assistant in the lower year. B Patients will undergo complete intravenous anesthesia using the maximum combined dose of propofol and dexmedetomidine. In group C, patients will undergo inhalation anesthesia using isoflurane and nitrous oxide.

The present study will be conducted in a double-blind method, so that neither patients nor the evaluators of the study outcomes are aware of the placement of patients in the study groups. In addition, fair people are placed in groups. Syringes prepared with different concentrations that have reached the same volumes with normal saline for bolus injection and Prepared microstructures with different concentrations (2 groups of maximum and minimum dose) that have reached the same volumes with normal saline, for infusion during operation A low-year resident or anesthesiologist present at the patient's bedside who do not know the concentration of the drug And record only clinical signs and vital signs