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Study aim
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Comparing the effect of local anesthesia caused by intradermal injection of ketamine with lidocaine in venous venipuncture in the emergency department of Boali Hospital
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Design
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A clinical trial with a control group, with parallel groups, double-blind, phase 2 on 246 patients.
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Settings and conduct
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In group (a), 0.2 ml of buffered lidocaine, is injected intradermally. In group (b), we inject 0.2 ml of 1 mg ketamine solution intradermally, and in group (c) we inject 0.2 ml of normal saline.
Venipuncture will be done After two to three minutes. The method of blinding is as follows: ketamine, lidocaine, and normal saline in 100 ml vials. The same will be poured and one of the letters a, b, c will be written on each one, and the patients will be randomly divided into three groups and receive a coded vial.
Visual analog scale use for assessing patients.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria include the age range of 18-60 years, alertness and ability to communicate verbally, provide written consent and the need to take a venous vein under the supervision of a physician. Patients with unwillingness to continue to participate in the study, history of allergies to local anesthetics (lidocaine / prilocaine, tetracaine and benzocaine), opioid addiction, severe analgesia addiction, peripheral vascular diseases, sensory disorders such as diabetic neuropathy, cognitive disorders , And a history of needle phobias and panic attacks are excluded.
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Intervention groups
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246 people in three groups of 82 people are divided into 3 groups receiving buffered lidocaine, ketamine and placebo (normal saline).
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Main outcome variables
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the amount of pain caused by venipuncture, heart rate (dependent variables);