Comparison of the effect of Swalin ointment and 1% Silver sulfadiazine on the repair of 2nd degree deep burns

Comparison of the effect of Swalin ointment and 1 Silver sulfadiazine on the repair of 2nd degree deep burns

A randomized, single-blind, interventional, control group clinical trial, phase 3 on 82 patients. The randomization tool of this study is Excel software and this software is also used to create a random sequence.

Patients with deep 2nd degree burns who refer to Shahid Motahari Burn Hospital in Tehran during the study, if they are eligible, will be included in the study and will be randomly assigned to the intervention and control groups using the random block method. This study will be conducted in a double-blind manner, so that the patients and the doctor examining the patients will not know the type of intervention.

Age 15-45 years, deep 2nd degree thermal burn wound of the body less than 10% in total, good general condition and no underlying disease such as diabetes, no history of autoimmune diseases, no HIV infection, no history of taking immunosuppressive drugs, No history of immune system deficiency, no history of hospitalization in the psychiatric ward, no history of burns. Conditions for not entering the study:other types of burns such as chemical, electrical, etc., wound stained with polluting substances, use of any substance other than drinking water on the wound before entering the study, untreated active infection in different parts body, patients with underlying diseases and immune system defects such as cancer, AIDS, diabetes, high blood pressure, etc., burns on the face and genital areas, pregnant and lactating women.

In the first group of patients with deep 2nd degree burns and treated with 1% silver sulfadiazine ointment, and in the second group of patients with deep 2nd degree burns and treated with Swalin ointment.

The size of the burn surface

Randomization in this study is done through block randomization with 6 blocks. The randomization unit is an individual type. The randomization tool of this study is Excel software and this software is also used to create a random sequence. For concealment, an experienced person who is not one of the project collaborators, in a separate center after registering the participants' information, defines the ointment code separately for each patient and informs the research team about the corresponding code.

In this study, the researcher, doctor and data analyst, who is responsible for collecting information, do not know the type of drug used, all patients are fully informed about the type of ointment used, and a written consent form is completed for each of them, and all treatment steps are also It will be under the supervision of the center's specialist doctor.