Comparison of opioid requirement and pain intensity after mandibular surgeries in intraoperative infusion and bolus injection during dexmedetomidine extubation: a randomized clinical trial

Comparison of opioid requirement and pain intensity after mandibular surgeries in intraoperative infusion and bolus injection during dexmedetomidine extubation: a randomized clinical trial

A clinical trial with parallel intervention groups, double-blind, randomized, on 40 patients. The sampling method is random. Randomization using a table of random numbers is the Random Allocation Software.

Among the patients referred to the Maxillofacial Surgery Department of Imam Reza Hospital In Tabriz who are candidates for mandibular surgery, they participate in the study. Patients are randomly assigned to one of the groups. In the first group, after surgery and before extubation, dexmedetomidine will be infused at the rate of 5.0 mg/kg, and in the second group, it will be injected exactly like the first group, but by bolus method. The intensity of pain during recovery, the first, second, fourth, sixth, twelfth, and twenty-fourth hours after discharge from recovery will be measured using VAS. Also, the number of times needed for opioid medication will be recorded if the pain intensity of the patients is higher than 5. The researcher is aware of the existence of two types of treatment, but he does not know which method of medicine he received in each group. Data analysts are not aware of the type of intervention.

Including criteria: candidate for mandibular surgery, duration of surgery less than 4 hours Excluding criteria: sensitivity to dexmedetomidine, non-cooperation in the study

Intervention 1: Injection of dexmedetomidine infusion after surgery Intervention 2: bolus injection of dexmedetomidine after surgery

The amount of pain؛ frequency of needing opioids

Random sampling will be done among the patients referred to the maxillofacial surgery department of Imam Reza Hospital in Tabriz who are eligible for the study. The randomization method is simple and its unit is individual. Random numbers are our tool for randomizing. Based on this, the type of treatment is marked with code A (infusion) and B (bolus) and placed inside sealed envelopes. Then the envelopes are placed in a bag and mixed. Then it is randomly selected from the bag and treatment is given to the patient by observing the code. None of the patients will be informed about the treatment of another patient.

This study is double-blind. The injection will be done by an anesthesiologist. The researcher who will conduct the evaluation will not know about the type of intervention performed. Also, the person analyzing the data will be unaware of the type of intervention.