‏ Comparative study of the effect of metformin and empagliflozin on cardiometabolic, anthropometric and hormonal factors in women with polycystic ovarian syndrom

Comparing the effect of metformin and empagliflozin on cardiometabolic, anthropometric and hormonal factors of women with polycystic ovary syndrome.

A clinical trial with a control group, with parallel groups, phase 3, randomized with random allocation software, is conducted on 50 patients.

This research is a clinical trial that is conducted on women aged 15 to 55 with polycystic ovary syndrome who refer to Imam Ali Shahrekord Clinic. For three months, the intervention group is treated with empagliflozin tablets and the control group is treated with metformin tablets. Before and after the intervention, anthropometric, hormonal and cardiometabolic factors are measured in both groups and compared at the end.

Inclusion criteria: women aged 15-55, polycystic ovarian syndrome Exclusion criteria: Diabetes, pregnancy, urinary tract infection

Patients are divided into 2 groups, empagliflozin group and metformin group. The intervention group received empagliflozin 10 mg tablets (Abidi company) daily for 3 months, and the control group received metformin 1000 mg tablets (Raha Daroo company) daily for three months.

Weight, body mass index, waist circumference, fasting sugar, Hba1c, total testosterone, 17-oh progesterone AST, ALT, HOMA-IR, CRP, triglyceride, LDL, HDL, total cholesterol, fasting insulin, Dehydroepiandrosterone

Patients are randomly divided into two groups using balanced block randomization with a sample size of 4 samples in each block and random allocation of samples in both groups with the help of random allocation software. The result of random allocation is done by the consultant of methodology and study statistics and the type of allocation treatment is recorded on paper and each sample is placed in a separate package with a sample order code. When surgery is performed, clinicians who do not know the outcome of the allocation process in each sample until the time of surgery will open the packages.