Investigation of the effect of the formulated ginger rhizome capsule on blood pressure in prehypertensive patients.

Investigation of the effect of the formulated ginger rhizome capsule on blood pressure in prehypertensive patients referred to Khorram Abad health center

A clinical trial with randomized intervention and control groups

Patients aged between 30 to 70 years with systolic pressure between 120 and 139 and diastolic between 80 and 89 mmHg are randomly divided into two groups of intervention and control. The intervention group will receive capsules containing 26 mg of gingerol and the placebo group will receive capsules containing 400 mg of wheat starch. Then, blood pressure and its clinical consequences will be examined. The patient's blood pressure and other relevant variables including systolic, diastolic, mean arterial pressure, and pulse pressure are measured using a digital sphygmomanometer. Also, cholesterol, triglycerides, LDL, and HDL are measured by taking blood samples from patients and using an autoanalyzer in Ashair Khorramabad Hospital. Nitric Oxide Assay Kit and ELISA reader are used to measuring NO.

Inclusion criteria include patients aged between 30-70 years with the diagnosis of prehypertension and hyperlipidemia recently or at least during the last three months. Exclusion criteria include a history of high blood pressure or diabetes, taking blood pressure medications

The intervention group received 26 mg daily gingerol capsule in addition to the standard treatment regimen of the control group.

Decreased blood pressure

Patients will be divided into two groups using the stratified blocked randomization method. In this way, considering the gender (female, male), a stratum will be formed and within this stratum, the samples in the form of four blocks will be randomly assigned to the desired groups.classes are considered in order to match the two study groups of gender and BMI (thin and normal, obese and overweight).in this study, four classes are formed and the samples are randomly assigned to the subject group in the form of blocks of four.study will be assigned.in the present study,76 people were treated, 38 patients were treated with the original drug and 38 patients were treated with placebo.In this study, the 4-layer randomized block method is used to randomly assign patients to two groups A (drug group) and group B (control group). To do this, first by considering the classes as the age range (70-30) and over 70 years within each class, a list of blocks is written and numbers are assigned to them. (AABB (1) - ABAB (2) -ABBA (3) -BBAA (4) - BABA (5) - BAAB (6)). Then, using a table of random numbers, the numbers between one to 6 (for example, 1,4,5, etc.) are randomly selected, and finally the list of treatment assignments will be formed based on a sequence of letters A and B.

This study is a double blind and the patient, the treatment evaluator are unaware of the experimental group.medicines are made in the same way,the patient and the person who gives the medicine to the patient have no information about the type and content of the medicine.