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Study aim
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Investigating the effect of ketogenic diet on fatty liver
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Design
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A clinical trial with a control group, parallel groups, without blinding, randomized, on 60 patients, randomization blocks were performed with random allocation software.
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Settings and conduct
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The study is conducted on 60 patients with fatty liver who were referred to the gastroenterology clinic of the Velayat hospital. Patients will be divided into two groups receiving a common diet and a ketogenic diet. The level of liver enzymes and ultrasound findings are checked at the beginning and 3 months after the start of treatment.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria:
Patients with Non-alcoholic fatty liver disease;
Body mass index of more than 25 kg/m2;
Patient age between 20 and 60 years;
Not receiving the diet and exercise program in the past year;
Exclusion criteria:
Suffering from chronic kidney diseases, heart diseases, and other liver; diseases (hepatitis, liver cirrhosis), diabetic patients treated with insulin;
Pregnancy or breastfeeding among female participants;
Unwillingness to participate in the study;
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Intervention groups
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Control group: common diet (a low-calorie diet that is high in carbohydrates (55%–60% of total daily energy intake) for 3 months.
Intervention group: Ketogenic diet (a high-fat, adequate-protein, low-carbohydrate diet(less than 20%). In this diet, foods containing meat, cheese, cream, healthy oils, nuts, and seeds, etc., are consumed instead of foods containing sugar, grains and starches, fruits except berries, beans and legumes, alcohol, etc. ) for 3 months.
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Main outcome variables
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Level of alanine aminotransferase, aspartate transamylase, low and high density lipoprotein, triglycerides, bilirubin in blood and degree of fatty liver in ultrasound