Postoperative rhythm disorders are a serious complication of open-heart surgery. The incidence of postoperative supraventricular arrhythmias has been reported to be 11–54%, and the incidence of ventricular arrhythmia to be 1.8–13%.because of high prevalence of cardiac arrhythmia after CABG, this study aimed to investigate the use of prophylactic magnesium sulphate on treating arrhythmias that may occur following coronary bypass grafting operations.
In this double blind randomized trial study, 174 CABG candidates recruited. Renal or heart failure patients excluded from the study. As well as who had the history of taking antiarrythmic drug .All participants divided in two groups. 87 patients were given 3 g of magnesium sulphate diluted in 100 cc of isotonic 0.9% solution intravenously for 2 hours at the following times: 12 hours prior to the operation, immediately following the operation, and on postoperative days 1, 2, and 3 (Group 1). The other group of 87 patients was given 100 cc. isotonic 0.9% as placebo, during the same time periods. Patients were monitored during the preoperative period and for at least 24 hours postoperatively. The rhythm follow-up of cases was confirmed by ECG at 0, 6, and 12 hours postoperatively, as well as on postoperative days 1, 2, and 3. Magnesium blood ion analysis: plasma Mg+2 levels were determined by spectrophotometric analysis of venous blood samples taken immediately after the operation and on postoperative days 1, 2, and 3. Total Mg+2 levels were recorded. At the same time, levels of Na+, K+, and Ca+2 were also determined, and their insufficiencies replaced in the patients. During the study PVC / min , VT,NSVT ,VF and AF were monitored and recorded in patients.