Evaluation of effect of 15% benzydamine mouthwash on pain perception during palatal local anesthesia injection in patients candidated for periodontal surgery.a cross-clinical trial

Evaluation of effect of 15% benzydamine mouthwash on pain perception during palatal local anesthesia injection in patients candidated for periodontal surgery

A clinical trial with a control group, cross-over groups, double-blind, randomized with phase 3, on 86 patients, was used to randomize the Rand function of Excel software.

: Guilan Faculty of Dentistry Clinic. How to notify people to enter the plan: from among the people who refer to Guilan Dental School.

People 20-60 years old / with systemic health (without cardiovascular diseases, high blood pressure, diabetes, thyroid diseases, liver, etc.) who need maxillary posterior sextant crown lengthening surgery/gum graft/flap surgery in Posterior sextants have high jaws. Exclusion criteria: 1. Presence of diabetes, cardiovascular disease and hypertension 2. Cigarettes 3. Taking NSAIDS drugs during the last 6 months 4. Pregnancy 5. Taking painkillers within 24 hours before surgery

Intervention group: the use of 15cc of 0.15% benzydamine hydrochloride mouthwash for each patient is gargled for one minute. Control group: the use of 15cc of washing serum for each patient is done by mouth gargling for one minute.

The amount of pain

Based on the gradual sampling method of visiting the clinic, the patients were divided into two groups using 0.15% benzyd amine hydrochloride mouthwash (43 people) and using washing serum as a placebo group based on four random blocks. 43 people) are randomly assigned. The method used to generate the random allocation sequence by mentioning the name of the software or the site used: the random allocation sequence based on www.sealede envelope.com and the Random Block software will be used online. Then, in order to hide, the sequence list in the center The dental school research will be placed in a sealed envelope. After the permission to run this clinical trial, the type of interventions will be determined from inside the envelope based on the list in the daily visits of the patients.

Patients and operators are aware of the type of general grouping (which is divided into two categories of using benzydamine mouthwash and washing serum), but they do not know the order of entry into the grouping.. Before performing the work, two containers of the same color, whose contents cannot be distinguished from each other, are prepared by a person other than the operator and the patients, then before the operation, two containers are prepared by a person other than the operator and the patients, then Washing serum (Shahid Ghazi Company-Iran) is placed in one container and 0.15% benzyd amine hydrochloride mouthwash (Elixir Borujard Company-Iran) is placed in another container.First, group A patients are given 15cc of 0.15% benzyd amine hydrochloride mouthwash, and group B patients are given 15cc of serum to gargle for about a minute. After that, by the operator, for all the subjects, an infiltration injection with lidocaine 2% (1:100,000 epinephrine) (Exir Borujerd Company, Iran) was performed in the right posterior sextant of the upper jaw with an injection syringe and a 27 gauge dental needle with a length of 30 mm. can be The operator then scored the VAS (Vas is scored on a 100 mm horizontal line with the left endpoint marked "no pain" and the right endpoint "pain as bad as it can be.") for each patient. It registers immediately after the injection. All necessary surgical procedures are performed for each patient.In the next session, two containers whose contents cannot be distinguished from each other are prepared by someone other than the operator and the patients, in one container washing serum (Shahid Ghazi Pharmaceutical Company - Iran) and in the other container 0.15 benzyd amine hydrochloride mouthwash. % (Broujerd Elixir Company-Iran) is placed. Half of the patients who were given 15cc of 0.15% benzyd amine hydrochloride mouthwash last week are given 15cc of serum to gargle for about a minute. And vice versa, 15cc of benzydamine hydrochloride mouthwash is given to the patients who were washed with serum last week to gargle.After that, by the operator, this time for all the subjects in the left posterior sextant of the upper jaw, an infiltration injection with lidocaine 2% (1:100000 epinephrine) (Exir Borujerd Company-Iran) with an injection syringe and a 27-gauge dental needle head. 30mm is done. Then the operator records the VAS again for each patient immediately after the injection. Again, all surgical procedures are performed according to the previous procedure.

Age, gender, pain level of the study group All data can potentially be released after identifying individuals

Access starts 6 months after the results are published

For researchers working in academic and scientific institutions and people working in industry.

It can be used for research work or comparison with the intended study. It is possible to access the data by referring to the Research Science Center of Gilan Faculty of Dentistry and the person in charge, Mrs. Alavi.

It is possible to access the data by referring to the Research Science Center of Gilan Faculty of Dentistry and the person in charge, Mrs.sana Alavi. Responsible persons: Shida Dadashi Navi 09387181876 Mrs. Alavi: 09119431009

First, refer to the Science Research Center of the Faculty of Dentistry. Then they will be referred to the responsible person, Mrs. Shida Dadashi Navi, after the approval of the responsible person, it is possible to access the data.