Protocol summary

Study aim
The comparison of treatment using Movement System Impairment method with routine physical therapy in patents with knee pain
Design
A randomized clinical trial study, dabble-blind, parallel-group, 40 patients with knee pain randomized to one intervention group and one control group through web-based randomization
Settings and conduct
After evaluation by a physician, and inclusion-exclusion criteria, the researcher records the personal information of patients among with the signed consent form. Patients are gathered from clinics affiliated to Tehran University of Medical Sciences. After that, the pain records along with lower extremity functional questionnaire. Then, the alignments of thigh, shank and knee records in different positions of daily activities and the pain adds as well. Then, a syndrome is allocated to each patient based on the findings of researcher. Being categorized to a treatment group by randomization, then the patient receives the special treatments of each group. Exercises of Movement Impairment System group consists of specific exercises of each syndrome while routine physiotherapy group consists of stretching and strengthening exercises. Both groups are evaluated again after 6 weeks and the results are compared by statistical tests.
Participants/Inclusion and exclusion criteria
Inclusion criteria: Age between 18-65, Knee pain at least 2 months before enrollment, Pain scale of 30-70 based on a Numeral Rating Scale. Exclusion Criteria: The confirmation of the need for surgery. Systematic, Metabolic, or Neurologic disease (such as radiculopathy) Pregnancy. The need for analgesic or anti-inflammatory drugs during the treatment period
Intervention groups
Treatment with Movement System Impairment method Treatment with routine physiotherapy method
Main outcome variables
Pain, Function, Knee Alignment

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20180627040251N5
Registration date: 2023-03-30, 1402/01/10
Registration timing: registered_while_recruiting

Last update: 2023-03-30, 1402/01/10
Update count: 0
Registration date
2023-03-30, 1402/01/10
Registrant information
Name
Hassan Sadeghi
Name of organization / entity
Kharazmi University
Country
Iran (Islamic Republic of)
Phone
+98 21 2222 8001
Email address
hassan.sadeghi81@yahoo.com
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2023-03-28, 1402/01/08
Expected recruitment end date
2023-04-28, 1402/02/08
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The comparison of treatment using Movement System Impairment method with routine physical therapy in improving pain and function in patents with knee pain: A randomized clinical trial
Public title
Comparison between MSI and routine physiotherapy treatments in knee pain patients
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
Knee pain at least 2 months before examination Pain between 30-70 based on "Numeral Rating Scale"
Exclusion criteria:
The confirmation of the need for surgery Systematic, Metabolic or Neurologic disease (such as radiculopathy) Pregnancy The need for analgesic or anti-inflammatory drugs during the treatment period
Age
From 18 years old to 65 years old
Gender
Both
Phase
N/A
Groups that have been masked
  • Participant
  • Outcome assessor
  • Data analyser
Sample size
Target sample size: 40
Randomization (investigator's opinion)
Randomized
Randomization description
Participants will be randomized into intervention and one control group using an online randomization system (randomizer.org). A member of the research team who is not involved in the selection of samples will determine the randomization sequence using a computer program. Participants will be notified of their group allocation with a sealed envelope.
Blinding (investigator's opinion)
Double blinded
Blinding description
The patients are aware of the study, but they are not aware of each exercise in each method and only perform each given exercise. Then the patients are evaluated by an examiner while another person teaches the exercises to patients. At the end of study, the patients are again assessed by the same examiner while the examiner is not aware of patient's grouping. Furthermore, the statistician analyzes the data who is not aware of each treatment group's conditions.
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Sport Sciences Research Institute (SSRI)
Street address
No. 3, 5th Alley, Miremad Street, Motahhari Street, Tehran, Iran
City
Tehran
Province
Tehran
Postal code
1587958711
Approval date
2022-08-22, 1401/05/31
Ethics committee reference number
IR.SSRC.REC.1401.067

Health conditions studied

1

Description of health condition studied
Knee pain
ICD-10 code
M25.56
ICD-10 code description
Pain in knee

2

Description of health condition studied
Chronic pain
ICD-10 code
G89.4
ICD-10 code description
Chronic pain syndrome

Primary outcomes

1

Description
1) Pain score based on Numeral Rating Scale of 0-100. 100 shows the worst pain and 0 is the least amount of pain.
Timepoint
At the start of the study (Before intervention) and 6 weeks after the start of the study (End of study)
Method of measurement
Pain is evaluated by marking on a line which is divided to 100 points.

Secondary outcomes

1

Description
knee alignment
Timepoint
At the start of the study (Before intervention) and 6 weeks after the start of the study (End of study)
Method of measurement
Knee alignment is measured in standing, sitting, walking, standing on one leg, and stairs position.

2

Description
Function based on questionnaire of Knee injury and Osteoarthritis Outcome Score. The score is a percentage score from 0 to 100, 0 representing extreme problems and 100 representing no problems
Timepoint
At the start of the study (Before intervention) and 6 weeks after the start of the study (End of study)
Method of measurement
The function is measured by Knee injury and Osteoarthritis Outcome Score questionnaire.

Intervention groups

1

Description
Intervention group: This group consists of patients with knee pain that are treatable with physiotherapy after initial assessment. In this group, patients are classified based on “Movement System Impairments “ (MSI) method. In this system of classification of patients, they are categorized in one of the MSI groups based on the signs and symptoms consisting of pain (primary variable) and function (secondary variable) in different positions (secondary variable). Since each group has a different characteristic in comparison to others, patients are treated based on the group they are categorized in. Treatment consists of strengthening each category. These exercises are prescribed based on the problem in each group. Moreover, the patient will be taught what to be cautious about, what to avoid, and what needs to be done in daily tasks. If there is a desire for the taping of the patellar bone to correct the patellar alignment through the treatment, it will be done, as well. Stretching exercises are another part of the exercises that might be prescribed based on necessity. These exercises are performed for 6 weeks.
Category
Rehabilitation

2

Description
Control group: This group consists of patients with knee pain that have been diagnosed as treatable by physiotherapy while they are not categorized in specific groups. Their treatment is based on routine physiotherapy exercises. The term routine physiotherapy consists of training knee pain through muscle strengthening exercises, stretching, and teaching the positions that the patient should avoid without being in a specific group. All these treatments are taught to all patients. These exercises continue for 6 weeks.
Category
Rehabilitation

Recruitment centers

1

Recruitment center
Name of recruitment center
Faculty of Sport Sciences. Kharazmi University
Full name of responsible person
Azam Ahmadi
Street address
No 1. Kusha St. Hesari St. Mirdamad. Shahid Keshvari Sports Complex,
City
Tehran
Province
Tehran
Postal code
1544733111
Phone
+98 21 2222 8001
Email
labrotary.pess.khu@gmail.com

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Kharazmi University
Full name of responsible person
Dr Mohammad Delnavaz
Street address
3th floor. Faculty of sport science and Physical Education, Shahid Keshvari Sports Complex, Razan Jonobi, Mirdamad,
City
Tehran
Province
Tehran
Postal code
33111-15447
Phone
+98 21 2222 8001
Fax
Email
abbasi@khu.ac.ir
Web page address
https://pess.khu.ac.ir/index.php?sid=42&slc_lang=en
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Kharazmi University
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Kharazmi University
Full name of responsible person
Dr. Hassan Sadeghi
Position
Assistant Professor
Latest degree
Ph.D.
Other areas of specialty/work
Sport Medicine
Street address
3th floor. Faculty of sport science and Physical Education, Shahid Keshvari Sports Complex, Razan Jonobi, Mirdamad,
City
Tehran
Province
Tehran
Postal code
33111-15447
Phone
+98 21 2222 8001
Email
Hassan.sadeghi81@yahoo.com

Person responsible for scientific inquiries

Contact
Name of organization / entity
Shiraz University of Medical Sciences
Full name of responsible person
Mohammadreza Farazdaghi
Position
consultant
Latest degree
Ph.D.
Other areas of specialty/work
Physiotherapy
Street address
Chamran Blvd.-Abiverdi Ave.
City
Shiraz
Province
Fars
Postal code
71345-1733
Phone
+98 71 3627 1552
Email
mfarazdagh@gmail.com

Person responsible for updating data

Contact
Name of organization / entity
Kharazmi University
Full name of responsible person
Dr. Hassan Sadeghi
Position
Assistant Professor
Latest degree
Ph.D.
Other areas of specialty/work
Sport Medicine
Street address
3th floor. Faculty of sport science and Physical Education, Shahid Keshvari Sports Complex, Razan Jonobi, Mirdamad,
City
Tehran
Province
Tehran
Postal code
33111-15447
Phone
+98 21 2222 8001
Email
Hassan.sadeghi81@yahoo.com

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Undecided - It is not yet known if there will be a plan to make this available
Study Protocol
Undecided - It is not yet known if there will be a plan to make this available
Statistical Analysis Plan
Undecided - It is not yet known if there will be a plan to make this available
Informed Consent Form
Undecided - It is not yet known if there will be a plan to make this available
Clinical Study Report
Undecided - It is not yet known if there will be a plan to make this available
Analytic Code
Undecided - It is not yet known if there will be a plan to make this available
Data Dictionary
Undecided - It is not yet known if there will be a plan to make this available
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