Evaluation of the effect of platelet-rich plasma in the treatment of shoulder tendonitis

۱- Evaluation of the comparative effect of platelet-rich plasma and corticosteroid injections in tendonitis patients ۲- Investigating the effect of platelet-rich plasma in relieving tendon inflammation ۳- Assessment the effect of platelet-rich plasma in reducing pain

Two study groups have been designed. that patients are randomly divided into two groups. 100 patients are selected in each group. This clinical trial study has a control group, with parallel, double-blind and randomized groups. Processing of platelets and how to select patients to enter the study have been considered in this project.

This project is carried out in the Orthopedic Department of Imam Hospital and the Research Center and Transplant Products Bank. The injection patients are selected by the doctor and samples are prepared in the research center. To prepare PRP, 20 cc of blood is taken from patients. At first, the questionnaire is completed by the patients. The consent form is also completed by the patients

A shoulder injury that has lasted more than 3 months, the range of motion of their shoulder joint is limited, the absence of radicular pain, the absence of inflammatory disorders such as rheumatoid, and the absence of a complete rotator cuff tear, and the absence of corticosteroid injections in the past three months. The patient's unwillingness to continue treatment and perform shoulder joint surgery and the occurrence of other joint disorders

There are two groups including PRP injection and coronet injection group. Cortone group is the control group. In this study, the effect of PRP compared to corticosteroids is investigated.

Shoulder internal and external rotation range of motion, Shoulder internal and external rotation strength, the pain, Ultrasound findings

The simple random allocation method is that from the beginning, the intervention group (platelet-rich plasma) will be given odd numbers and the control group (Corton) will be given even numbers. Then, according to the number of the studied sample, the corresponding numbers are extracted using the computer, each number is written on a card and placed in an envelope, the envelopes are sealed, and the patient's name is written on each envelope. An envelope is given in order of numbers. In order to maintain randomization, the person who prepares the envelopes is different from the person who registers the patients and provides the envelopes to the patients. Registration of patients and their allocation in each of the groups is done by someone other than the doctor.

For one group, PRP injection was performed, and in this method, the patient had one PRP injection. In this group, 20 cc of venous blood was takenIn this case, 3 cc of liquid containing platelets with 5 to 6 times concentration will be obtained.The samples will be sent to the laboratory before and after centrifugation to prove platelet concentration. Then, with another syringe, the remaining 3 cc is injected under ultrasound guidance at the tendon tear site. In the other group, corten injection is done intra-articularly. In order to blind the patients, a blood sample is taken from this group before the injection, and in order to maintain medical ethics, the blood sample is sent to the laboratory to count the blood cells. Also, when injecting, adhesive tape is used around the syringe so that the patient does not notice the injected substance.

Data will be shared after de-identifying individuals on pain, range of motion, shoulder function, and tendon thickness.

6 months after the results are published

For researchers and workers in academic centers

For use in research or essays

by e-mail or mobile and request on the research gate website

It will be sent to the applicant by email 3 months after the request