This is a randomized controlled trial which the primary outcomes measure include reducing fatigue and increasing quality of sleep in female students with Premenstrual Syndrome (PMS). Census sampling method will be used to screen PMS in the students of Islamic Azad University and Payam e Noor University in Bandar Genaveh, Bushehr Province. Then, 140 students with PMS and the inclusion criteria will be selected consecutively and randomly assigned to two groups of experiment (intervention) and control (with Blocking Randomization Method). The inclusion criteria include: students with fatigue and sleep quality score of 31 and 5, respectively; regular menstruation of 24-35 days; age of 18-35 years old; not married; no physical and mental diseases; no medication or traditional treatment for controlling PMS; The exclusion criteria consist no interest for participation in the trial anymore; performing incomplete acupressure for less than 6 consecutive days for any reason; irregular menses; get married during the trial; pharmacological or non-pharmacological treatments for PMS during the trial. For data collection, a self report questionnaire will be used for Premenstrual Syndrome diagnosis. Fatigue Severity Scale (FSS) and Pittsburg Sleep Quality Index (PSQI) will be used to measure the main dependent variables in the study. The independent variable will be acupressure on the points of ST36 – below the knee, in the anterior boarder of tibia and HT7 in the hands, at the wrist crease, on the radial side of the flexor carpi ulna is tendon, between the ulna and the pisiform bones. The intervention (acupressure) will be applied for 5 minutes on each points of the body. In other words, the total duration of intervention will be 20 minutes per day for 5-10 days premenstrual period in two consecutive cycles. The procedure of acupressure will be confirmed if subjects felt sore, numb, heavy, distended, and/or warm as a result of acupressure massage.