Investigating the effect of low-dose aspirin on the success rate of ovulation induction in women with polycystic ovary syndrome

Determination of the effect of low-dose aspirin administration on the success rate of ovulation induction in women with polycystic ovary syndrome.

A clinical trial with parallel groups, double-blind, randomized, on 80 patients. Blocks of 4 were used for randomization.

Patients suffering from polycystic ovary syndrome disease with the inability to ovulate (both primary and secondary) referred to the women's clinic of Ba'ath Sanandaj Hospital in 1401 who meet the inclusion criteria and do not meet the exclusion criteria.

Enclusion criteria: age 20 to 35 years, body mass index less than 30 kg/m2, suffering from polycystic ovary according to Rotterdam criteria. Exclusion criteria: other causes of infertility, male factor, abnormal thyroid function tests, abnormal prolactin levels, diabetes, the anatomical disorder in hysterosalpingography or laparoscopy, endometriosis.

The first group: recipients of clomiphene citrate with a dose of 50 to 150 mg from the day of the 3rd cycle to 3 months after ovulation + placebo daily until pregnancy or the end of the study. The second group: received letrozole at a dose of 5 to 7.5 mg from day 3 of the cycle to 3 months after ovulation + a placebo daily until pregnancy or the end of the study. The third group: recipients of clomiphene citrate at a dose of 50 to 150 mg from day 3 of the cycle until 3 months after ovulation + oral aspirin at a dose of 80 mg daily from the third day of the previous menstrual cycle until pregnancy or termination. study The fourth group: recipients of letrozole at a dose of 5 to 7.5 mg from day 3 of the cycle until 3 months after ovulation + oral aspirin at a dose of 80 mg daily from the third day of the previous menstrual cycle until pregnancy or the end of the study.

pregnancy

Increase the sample size

Considering that there are 4 groups under investigation and each group receives one of A, B, C, or D treatments 4 random blocks are formed as follows: ABCD, ACBD, ADCB, ADBC, ACDB, ABDC, BACD, BCAD, BDCA, BDAC, BCDA, BADC, CBAD, CBDA, CABD, CADB, CDAB, CDBA, DBCA, DBAC, DCBA, DCAB, DABC, DACB, Each time and for every 4 new patients who will enter the study, one of the above blocks will be randomly selected, and based on the order in the selected block, they will receive one of the A, B, C, or D treatments.

This is a double-blind study. The patients and the main researcher do not know the type of treatment received by the groups. The statistical analysis will be done by another researcher who is unaware of the type of treatment received by the different groups.

The research data will be provided to the requestors without mentioning the personal characteristics of the research participants.

After the end of the research and confirmation of the obtained results and obtaining permission from the university, the information will be provided.

Government and private research institutes and people who are interested in research in the studied field.

In order to continue the research and complete the obtained protocol.

Research assistant of the faculty

The request will be submitted to the research vice-chancellor of the faculty. If approved, it will be sent to the supervisor, and if approved, the information will be provided to the applicant.