A comparative study the effect of anti-inflammatory diet and Barberry intake on liver fat accumulation, anthropometric and biochemical indices in 8-13 year obese and overweight children with non alcoholic fatty liver

Comparison of the effect of intaking anti-inflammatory diet and barberry on liver fat accumulation, anthropometric and biochemical indicators in 8-13-year-old obese and overweight children with non-alcoholic fatty liver

The current study will be conducted using a randomized clinical trial method. Children with obesity and overweight with fatty liver who meet the criteria for entering the study are selected and after obtaining informed consent to participate in the study, 48 of them will be selected as available for the intervention groups.

First, by attending the pediatric endocrinologist's office located in Kermanshah, obese and overweight children with fatty liver who meet the study entry criteria are selected. 48 people will be selected as available for the intervention groups. In this study, the amount of liver fat accumulation will be measured using the ultrasound method, the amount of liver enzymes and lipid profile will be measured through blood tests.

En Inclusion criteria: Age group of 8-13 years, lack of conditions such as Such as diabetes and cardiovascular disease, liver, kidney, thyroid disorder. Exclusion criteria: puberty, children who are professional athletes, use of any supplements (vitamins and minerals, etc.), the presence of digestive problems.

Study groups: intervention group 1 includes weight maintenance and anti-inflammatory diet along with receiving 3 grams of barberry before meal and intervention group 2 includes receiving 3 grams of barberry before meal, intervention group 3 will include weight maintenance and anti-inflammatory diet . Weight maintenance and anti-inflammatory diet containing 18% protein, 30% fat and 52% carbohydrates.

The degree of fatty liver

In this study, the block randomization method will be used to ensure that exactly the same number of participants enter the groups in a consecutive but equal time interval. At first, based on the sample size, we evaluate all possible states (permutations) of block formation, so that based on the sample size (48 people), 8 blocks of six will be produced. In each block, 6 of the three groups A, B, C (group A: intake of anti-inflammatory diet, group B: intake of barberry, group C: intake of barberry and anti-inflammatory diet) will be included twice. The blocks are produced by the statistics consultant and the envelope will be used to hide the blocks. We will assign people to three groups according to the group names in the blocks. Each of the blocks is numbered and will be used, that is, if block number 1 (for example, ABCABC) is selected by lottery, the first patient will receive treatment A, the second patient will receive treatment B, the third patient will receive treatment C, the fourth patient will receive treatment A, and the fifth patient will receive treatment B. The sixth patient will take C. For the 7th patient and onward, I consider one of the previously specified blocks by random drawing again, and for assigning people to groups, we consider the sequence of this block as the same as the first block. One of the potential problems in the blocking method is the disclosure of the last allocation in each block. This problem occurs when the study uses the blocking method with fixed blocks, which is not used in this study. Rather, the blocks are randomly selected. Software and sites also generate this block random sequence, such as: www.randomization.com www.sealedenvelope.com

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