Evaluation the effect of intravenous vitamin C injection during cesarean on the control of bleeding during cesarean and after that in pregnant women candidate for elective cesarean

Investigating the effect of vitamin C on the amount of bleeding during and after cesarean delivery

A randomized clinical trial with the parallel groups, with control group, double-blind, phase 3 with 30 patients. The block randomization method will be designed by using "www.sealedenvelope.com"

This study will be conducted in Kamali Hospital on women scheduled for elective caesarean section .The purpose of this study is to investigate the effect of vitamin C on the amount of bleeding during and after cesarean delivery .Participants will be randomly divided into two groups: one (intravenous injection of vitamin C before cesarean section) and two (no intervention). The participants are aware of the type of intervention, the person who checks the outcome, the surgeon and the statistician are not aware of the type of intervention. The amount of bleeding during and after cesarean section, pain, duration of hospitalization and duration of surgery are compared between two groups.

Inclusion criteria : Candidate for elective cesarean section, age 45-17 Exclusion criteria: Emergency caesarean section, abnormal coagulation test results, Escorbic acid sensitivity , Eyperoxaluria, Creatinine more than 1.5 - UI, Having thalassemia, gout, cystinuria and G6PD deficiency , Oxalate kidney stones and Obesity

Intervention group: two hours before induction of anesthesia, a vial of vitamin C is injected intravenously from Royan Daro Pharmaceutical Company. Control group: without the use of drugs and intervention

The amount of bleeding during and after cesarean section

The method of random allocation is block and the unit of randomization is individual. The blocked randomization list will be designed using www.sealedenvelope.com. The randomization list will be prepared by the statistician. The treatments will be placed in sealed envelopes according to the block randomization list, which will be kept by the ward nurse who is out of the study. After the patient's eligibility is determined, the procedure is explained to the patient and ethical consent is obtained. Then the nurse provides the envelope containing the type of treatment to the doctor, and the type of treatment is performed based on the treatment in the envelope.

The statistician will be unaware of the intervention method. Because of the type of intervention, the participants know about the type of intervention. Injections are performed by a person who is not part of the operating room staff. As a result, the surgeon and assistant surgeon and the person who records the final result of the study are unaware of the type of intervention.