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Study aim
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Determining the effect of vitamins E, C and D individually and synergistically on pain syndrome and withdrawal anxiety caused by drug withdrawal
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Design
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Clinical trial with a control group, with parallel groups, without blinding, randomized, phase 3 on 125 patients. The rand function of Excel software was used for randomization.
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Settings and conduct
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After obtaining written consent, 125 drug addicts admitted to Mehr Nervi and Psychiatric Hospital in Khorramabad will be assigned to 5 study groups by simple random method without blinding. These groups include control (without treatment), groups receiving one gram of vitamin C, one thousand units of vitamin D, 400 units of vitamin E and the combination of all three vitamins daily for ten days. Demographic and clinical information of patients will be recorded in the initial evaluation. At the beginning and end of the intervention, the pain and anxiety questionnaire is completed for the patients.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: Confirmed diagnosis of substance dependence, Men over 18 years old, The emergence of withdrawal syndrome with the diagnosis of a psychiatrist, Has a score of at least 3 in the VAS test, Exclusion criteria: Taking multivitamin, mineral and antioxidant supplements in the last 3 months before starting the intervention, Liver or kidney failure
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Intervention groups
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Group one includes samples that do not receive any vitamins. Group 2, 3, 4 and 5 are respectively patients who, in addition to receiving standard treatment, receive 1000 vitamin D capsules, 400 vitamin E capsules, 1 gram effervescent vitamin C tablets and the combination of all three vitamins for ten days.
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Main outcome variables
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Anxiety and pain from addiction withdrawal