Assessing the effect of adding magnesium sulfate to Boupivacain for caudal anesthesia on postoperative pain in pediatric inguinal hernia repair surgery

Determining the effect of adding magnesium sulfate to bupivacaine in caudal anesthesia on pain after children's inguinal hernia repair surgery.

Interventional study, double-blind, randomized, therapeutic, with parallel groups, 50 patients will be randomly divided into two equal groups, bupivacaine group and bupivacaine + magnesium sulfate group.

The two groups will be matched in terms of age. Patients of both groups will be under general anesthesia with the same drug by an anesthesiologist with the same technique. Patients under caudal block in the lateral decubitus position will be anesthetized from the sacral hiatus space; in the bupivacaine group, 0.5 cc bupivacaine will be added to 5 cc of normal saline or distilled water, and in the bupivacaine group, magnesium sulfate, 5 cc 20% magnesium sulfate will be added to 5cc of 0.5% bupivacaine

Inclusion criteria for children undergoing inguinal hernia repair surgery, American Anesthesiology Association (ASA) physical status, children 2 months to 7 years, absence of contraindications for caudal blocks. Exclusion criteria: patients with mental disorders, patients with coagulation disorders, history of allergic reactions to local anesthetics, history of underlying diseases

Bupivacaine group and Bupivacaine + magnesium sulfate group

Pain measurement

Sampling will be done by the random permutation block design method of two treatments with blocks of ten. First, 10 blocks of the composition (ABABABABAB) will be listed and a code will be assigned to each, then according to the sample size equal to 50, 5 blocks will be selected in this order that the letter A for The bupivacaine group and letter B will be considered for the bupivacaine + magnesium sulfate group. Patients will be randomly assigned to two groups A and B using Random Allocation computer software. By selecting the simple randomization method in the randomization method section and entering the total sample size determined in this software, numbers will be given to the patients and the patients will be entered into two groups based on the numbers given by the computer. Randomization will be done based on the permuted block randomization method. Each block will have 10 capacities. Based on the example of ABABABABAB, in each block, people are evenly assigned to two groups. 5 blocks will be built. After that, in each block, people are randomly assigned to bupivacaine group (A) (25 people) or bupivacaine + magnesium sulfate (B) group (25 people). In this study, randomization will be simple, in a box, numbers from 1 to 50 will be written on sheets of paper and placed inside the box in an unspecified manner. One sheet will be removed for each disease, if the number is even. It will be placed in the first group, and if it is an odd number, it will be in the second group.

All the codes are secret and while the examiner will be one person and they will not be informed about the grouping of people, the method and process of conducting the study will be explained to the parents before prescribing the medicine. The study will be double-blind, the parents of the patients and the clinical evaluator will be unaware of the placement of the patients in the study groups, in other words, both the parents will be unaware of the group they have been placed in, and the clinical evaluator will not know the group of the patients. Finally, after collecting the data of each group separately, they will be compared by the clinical assessor - who does not know about the patient group.