Evaluation the effect of co-enzyme Q10 supplementation on inhibition of ferroptosis in patients with thalassemia major referred to Shahrekord Hajer Hospital

Determining the effect of coenzyme Q10 on inhibiting ferroptosis in patients with thalassemia major

The present semi-experimental study is a before and after clinical trial without control group done on 50 patients with thalassemia major. In addition to the standard treatment, the patients also receive a 100 mg Q10 tablet daily for eight weeks. Before the study, the parameters of ferroptosis including superoxide dismutase (SOD), catalase, glutathione peroxidase, ferritin, hemoglobin, ESR and CRP will be evaluated, and after eight weeks of intervention, the parameters will be evaluated again.

50 patients are selected from the thalassemia patients referred to Hajer Shahrekord Hospital in 1402. These patients are selected in a similar way (patients who are similar in terms of blood collection intervals). this study is a before and after clinical trial without control group. The relevant laboratory parameters including superoxide dismutase (SOD), catalase, glutathione peroxidase, ferritin, hemoglobin, ESR and CRP will be measured for these patients before start intervention (baseline), and then, after eight weeks of taking one 100 mg Q10 tablet daily, in addition to the standard treatment, Patients will also receive the supplement

Inclusion criteria: patient with thalassemia major Exit criteria: Patient non-cooperation The presence of side effects People who suffer from infection and inflammation. death of the patient

The study will be a single group comparison before and after. The intervention group receives standard treatment + 100 mg Q10 tablets

The level of ferritin, superoxide dismutase, glutathione peroxidase-4 GPX4, catalase, hemoglobin, ESR, CRP

The data analyst does not know whether the collected data are related to before or after the intervention

To share the data and documents of this research, only the information related to the main outcome will be shared. Also, files that can be published and do not violate people's privacy will be published.

The access period will start 6 months after the results are published.

Our data will only be available to researchers working in academic and scientific institutions

If there are conditions, all our data will be shared except personal information of people. The use of our data will only be allowed for similar research and review of our data by other researchers. All those who work in universities and scientific centers and decide to conduct similar research or check the accuracy of our data can access our data.

In order to receive information, all eligible people can collect data by referring to the person in charge of the project. The contact methods are the email address shimarahmati1987@gmail.com or the contact number 00989139854865

To receive information after sending the request, the requests will be reviewed within 10 days. If the above conditions are met, the information will be sent to the provided email within 30 days at most.