The Effect of local dexamethasone injection after immediate implant placement

Determining the effect of local dexamethasone injection after implant placement surgery (Immediate implant)

A clinical trial with a control group, with parallel groups, double-blinded, phase 3 on 60 patients, randomized by block randomization method

All patients(both groups) receive the same surgery and drug except dexamethasone. An experienced surgeon with the same technique in the special clinic of the Sari Dental Faculty performs all surgeries. The person who follows the patients and records their pain and swelling levels will not be aware of the patient's group, and only the surgeon will be aware of the patient's groups.Also, none of the patient and control groups know whether the local injection was done. Patients' pain will be evaluated by VAS (Visual Analogue Scale), criteria and accompanying clinical conditions will be described for the patient, and according to the classification made by Pasqualini, patients will rate their pain and swelling from 0 to 5.These tests will be done within 48 hours,4 days later and then 7 days after the surgery through a phone call.

Inclusion criteria: Individulas aged 18 to 60 years who have no threatening systemic disease or allergy to dexamethasone. Exclusion criteria include pregnant people, threatening systemic disease, weak immune system, AIDS, sensitivity to the drugs used in the study, and recent use of antibiotics and anti-inflammatory drugs.

In the control group, subjects will not receive any corticosteroids. In the intervention group, immediately after suturing, dexamethasone will be injected with the help of an insulin syringe in the depth of the vestibule adjacent to the implanted tooth, and 1/3 vials of topical dexamethasone (8 mg from Alborz Darou Pharmaceutical Co.) will be used.

Pain; Swelling; Satisfaction with surgery

Randomization method: Block randomization (blocks of 4); Individual Randomization tool: The software of random allocation 2 Procedure of making a random sequence and hiding it: Using the software, codes A and B will be generated, where code A means the application of the dexamethasone group and code B means the application of the control group for each individual. Finally, the codes will be placed in the sealed envelope and the number of each patient will be written on the envelope. As each patient enters, the doctor will open the envelope and apply the desired treatment.

The person who follows the patients and records their pain and swelling levels will not be aware of the patient's group, and only the surgeon will be aware of the patient's groups. Also, none of the patient and control groups know whether the local injection was done(There is a placebo).