Comparison of the analgesic efficacy of pethedine and ketorolac in renal colic patients referred to imam khomeini hospital ilam city in 2022

Achieving a longer lasting analgesic effect in renal colic patients

A clinical trial without a control group, with parallel groups, double-blind, randomized, phase 2 on 108 patients, simple randomization method by number table was used for randomization.

The location of the study is Imam Khomeini (RA) Ilam Hospital, which is in the field of treating patients with renal colic. First, the pain level of each patient is recorded; Then the patients are randomly divided into 3 groups, the first group is given 25 mg of pethidine, the second group is given 30 mg ketorolac, and the third group is given a combination of 2 drugs. The medicinal solution is given to the patients by a nurse who has no knowledge of the study protocol. There is no information about the medicinal solution of different groups and there is no difference between them. If the verbal score of "no pain" or "much better pain" is not obtained, the life-saving drug pethidine 25mg this time is in the form of iv slow injection to be repeated every 15 minutes if needed. The functional status of the patient is calculated as follows: weak impairment: able to return to work and drive a car; moderate impairment: able to perform daily activities at home; severe impairment: confined to bed.

Eligibility: Renal colic patients with clinical and radiological diagnosis of kidney stones Exclusion conditions: 1_Pregnant women 2_Nursing mothers 3_Persons with kidney dysfunction before 4_Patients treated with warfarin 5_Patients with bleeding disorders 6_Persons with a history of gastrointestinal problems after taking NSAIDS

The first group is injected with 25 mg of pethidine the second group is injected with 30 mg of ketorolac and the third group is injected with a combination of ketorolac and pethidine.

Pain relief

Patients are individually divided into 3 groups by a simple randomization method by a table of numbers in such a way that each person is assigned a number according to the table and then randomly any number from the box The number 1 to 108 is placed in it, the first number is placed in the first group, the second number is placed in the second group, and the third number is placed in the third group, and the randomization continues in this way until the end, and none of the patients from The groupings and the difference between the intervention of the groups are no longer known.

All patients (participants) are not aware of the groupings and that the injection solution of each group is different, and the solution will be injected by a nurse who will not have any knowledge of the composition of the solution and the difference of the injection solution of different groups.