The effect of Dorema ammoniacum topical ointment on mild to moderate plaque psoriasis

Investigating the therapeutic effect of Dorema ammoniacum ointment on improving psoriasis skin lesions

clinical trial ; three blind study ; phase 3 The sample size was calculated by using the PASS software and for the test of the difference between the average pass score of two independent groups and considering the power of 90% and the confidence of 95% and the standard deviation of 3 and the effect size of 2.5 units in each group of 32 people, which considering It was determined that 3 people drop out in each group of 35 people.

Patients with psoriasis referred to Imam Reza Hospital in Mashhad, which has inclusion criteria, are assigned to intervention and control groups and receive Dorema ammoniacum ointment or placebo for four weeks. Clinical symptoms will be evaluated based on the PASI score at the beginning and end of the study. Patients, outcome evaluator and data analyst will be blind.

Inclusion criteria: Age 12 years and older, Suffering from chronic plaque-type psoriasis, The extent of infection is less than 10% of the body's surface Exclusion criteria: Having serious liver or kidney diseases, Using topical medicine in the last 14 days and systemic medicine in the last 30 days, Pregnancy or planning to become pregnant, breastfeeding, History of allergy to herbal medicines, Abnormal laboratory findings, Taking local or systemic medications that have a positive or negative effect on the course of the disease.

intervention , the test group consisted of ointment containing 15% ash, 10% vinegar, 20% wheat oil and 55% oserin. In the control group, topical ointment with the same color, smell and consistency as the original ointment is used.

Measurement of extent ٬ inflammation and scaling of the lesion

Block method Allocation Concealment : closed and sealed envelopes triple blinded : people under study assesors analystic in the placebo group the patient is unaware of the type of ointment . instead of intervention and control group A and B are used to blind the analyst . the evaluation of the outcome is done by a person outside the research group .

In the placebo group the patient is unaware of the type of ointment . instead of intervention and control group A and B are used to blind the analyst . the evaluation of the outcome is done by a person outside the research group .

Personal data of study participants can be shared after de-identification.

The access period starts 6 months after the results are published

Researchers working in academic and scientific institutions and people working in the industry.

Approved for use in the treatment of patients with plaque psoriasis Allowed for other statistical analyses

From Zahra Naseripour Yazdi with email address: Naseripz981@mums.ac.ir Phone number: 009809157101309

After mentioning the name and organization of the user and explaining the type of use of the information in the email address The specifications will be checked and will be made available after one month.