Comparison of the effect of sesame oil and 1% silver sulfadiazine ointment on the pain, healing and scarring of burn wounds

Comparison of the effect of sesame oil and 1% silver sulfadiazine ointment on the pain, healing and scarring of burn wounds

Clinical trial, double-blind with parallel groups, randomized, in phase 3, 40 patients will be selected as available and allocated by permutation blocks method.

The place of intervention was the emergency department of Bohloul hospital. For the sesame oil group, first, the wound area will be washed with sodium chloride and exposed to the open air for 5 minutes until it dries completely. Then, the wound area is smeared with 2 ml of sesame oil (for 10 square centimeters of the wound) and the surface of the wound is covered with freezer plastic and then it will be bandaged. For the silver ointment group, all the above steps have been done and the wound will be dressed with 1% silversulfadiazine ointment. At the end, the diagnosis of wound healing will be confirmed by a specialist. The emergency medicine physician and the data analyst will be unaware of the patient grouping.

Informed consent to participate in the study Age 20-60 years First and second degree burns with an extent of 1-10% Burns due to contact with a heat source or liquids Less than 6 hours passed from the time of the burn to the time of going to the treatment center Hemoglobin and total protein normal Absence of underlying diseases such as anemia, diabetes, cardiovascular diseases, malignancy and immune system deficiency Not taking painkillers and NSAIDs orally or topically until the first visit to the treatment center Confirmation by the doctor that the patient does not need to be hospitalized Not allergic to sesame oil

Dressing group with sesame oil, will be dressed with sesame oil. Dressing group with 1% silver sulfadiazine ointment, will be dressed with silver ointment.

Healing & scars

The patients were first selected by the available method and then divided into two groups of sesame oil and silver ointment by using 4 permutation blocks. In this method, the sesame oil group was coded with the letter A and the silver ointment group was coded with the letter B. The six possible states in the blocks included ABAB, BBAA, AABB, BABA, AAAA, BBBB, and each block was assigned a number. For every four selected people, a number will be selected according to the list, and people will be assigned to two groups of sesame oil and silver ointment in this way.

The emergency medicine doctor who will confirm the recovery of the patients will not know about the grouping of the patients. The data analyst will also be unaware of the grouping of patients.