evaluation of antifungal supplement properties of zataria multiflora - loaded nanostructural lipid carriers in the treatment of onychomycosis caused by filamentous fungi

Determining the antifungal effect of supplementing lipid nanostructures loaded with Shirazi thyme on patients with onychomycosis caused by filamentous fungi.

In this study, which is a double-blind clinical trial, 30 patients with the desired disease will be included in the plan, and out of 30 confirmed patients, 15 will be in the experimental group and 15 will be in the control group. All the patients After being referred by a doctor to a specialized mycology laboratory, the patient will be examined and if the microscopic observation and culture are positive, they will be included in the plan.

The location of the project will be in the specialized mycology laboratory of Mazandaran Medical Sciences, in Toubi Clinic, Mazandaran. After entering the sampling, the samples will be checked for fungal agents, and after recording the results, the patient will receive medicine or a placebo and will be evaluated at intervals of 2, 4, and 6 weeks.

Entry requirements: All patients with mild-moderate onychomycosis caused by filamentous fungi over 18 years of age who have not taken antifungal drugs a month before treatment. Exit conditions: 1- Taking antifungal drugs before and during the study 2- Children and infants 1-18 years old 3- Allergy to herbal products

Intervention and control group: For patients with onychomycosis caused by filamentous fungi, 1% nano thyme gel made in Mazandaran University of Medical Sciences in 60 gram tubes is used twice a day for 1 month. It is used as an auxiliary drug along with the main drug (Itraconazole) which is determined by a specialist doctor. The control group will receive a placebo in addition to the main drug, the same as the intervention group

Improvement of fungal lesions in terms of clinical and mycological criteria

In that study, nano thyme gel and placebo were prepared in completely similar packaging and drug tubes, and in order to observe random allocation, www.randomizer.org was used in such a way that by using the codes received from the site, the drug and The isolated placebo is then placed inside a similar envelope and presented to the patient in a completely random manner. Therefore, the patient will not be informed about the nature of the drug and the type of group it belongs to. Since the smell created by Shirazi thyme essential oil can cause deviations in the study, therefore, both the drug and the placebo are mixed together in a closed tube and the doctor or expert randomly gives the drug to the patient. Gives.

The patients participating in the study, as well as the researcher, including the master student who is responsible for their dissertation, as well as the physicians who perform the intervention, are among the people who are blinded in the study. The drug and placebo are both placed in similar envelopes. The fellow doctors and graduate students who are performing the intervention are not aware of its contents. Only the drug code and the patient code will be stated in the questionnaire. But the executor is aware of the code as an analyst and assigns it to control and intervention groups. Participants, on the other hand, are not aware of the contents of the envelope, but will be informed that their supplement may be a placebo.

The results of this study will be published in an article.

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