Comparison of short-term outcomes of abdominal wall repair in patients appendectomy with and without peritoneal repair

Comparison of short-term outcomes of abdominal wall repair in appendectomy patients, with and without peritoneal repair

A randomized clinical trial with a control group, with parallel groups, double-blind, will be done on 150 patients aged 4 to 18 years, who were diagnosed with acute appendicitis and underwent emergency appendectomy surgery in Madani Hospital in Karaj. Randomization will be done using permuted balance block randomization technique using STATA software.

Generally, appendectomy can be done by open or laparoscopic method. Usually, during laparoscopic appendectomy, peritoneum closure is not one of the preferred practices, but in open appendectomy, some surgeons pay special attention to closing the peritoneum. So far, many studies have investigated whether or not to close the peritoneum on postoperative outcomes. This clinical trial is conducted in Karaj Civil Hospital. In this study, randomization is done by permuted balance block randomization technique. In this double-blind study, patients will be unconscious during the surgery and will not be aware of the wound closure method. The research team will not be aware of the intervention performed on the patients. Patient information and surgical complications will be followed up to one month after the operation.

Inclusion criteria: patients aged 4 to 18 years with a diagnosis of acute appendicitis Exclusion criteria: presence of abdominal abscess, presence of purulent fluid during surgery, pregnancy, history of malignancy, chronic liver disease, chronic kidney failure, diabetes and psychiatric disorders.

Appendectomy patients with and without peritoneal repair

The primary outcome includes pain and the secondary outcome includes surgical complications such as rupture, infection, bowel obstruction, and mortality.

In this study, patients will be randomly assigned using the permuted balance block randomization technique. Blocks of four will be used in this study. Using STATA software, a chain of random numbers from 1 to 6 will be generated to reach the desired sample size. If the generated number is greater than 6, the next number will be generated regardless. The preparation of random allocation sequences of intervention and control groups and placing them in sealed envelopes and numbering with a 5-digit serial number, will be done by a third person, who is not involved in the design of the study. All envelopes have a number. There will be a 5-digit series that will be opened immediately after the patient entrance to the operation room, and the patients will be divided into two intervention and control groups.

In this study, the patients will be under anesthesia, during the surgery and will not be informed about how the wound is closed. The research team (interviewers) will not know which intervention was performed on which person.