Compare the effect of heparin lock and normal saline flushing on central venous catheter patency in patients admitted to the intensive care unit

Comparison of central venous catheter opening time between flushing with normal saline and heparin lock in patients

A randomized clinical trial of three groups with parallel groups and on 90 samples sorted using the site https://www.random.org/integers

This research is a clinical trial of three groups, the samples of which are hospitalized patients in the special care departments of Hashminejad and Imam Reza and Ghaem Hospitals in Mashhad. In patients whose central venous catheter has been in place for less than 24 hours, they are divided into three groups based on random allocation. In the first group, before clamping the duct, a solution of 30 units of heparin in a volume of 2 cc is injected into each duct and locked every 8 hours, and then the duct is clamped. 3 normal saline is washed every 8 hours. To check the openness of the central vein catheter, return without blood pressure into the syringe by aspirating with a 10cc syringe indicates that the catheter is open, and on the contrary, the duration of the catheter is recorded in hours. The duration of study for each group is 72 hours. After that, the researcher codes the data and enters SPSS software for analysis.

All hospitalized patients over 18 years of age hospitalized in the intensive care unit, less than 24 hours have passed since the placement of a three-channel central vein catheter in the subclavian region or internal jugular vein.

1. the channel of the central venous catheter is locked with a concentration of 30 units of heparin 2.the channel of the central venous catheter is locked with a concentration of 50 units of heparin Control group: The catheter canal is washed with 10 cc of normal saline solutio

Catheter duct opening/closing The length of time the catheter duct remains open

The selection of the research samples is such that all the people hospitalized in special care units, who have the conditions to enter the study, are selected as the research sample. A table was prepared for the order of patients entering the study. At first, 30 numbers from one to three, 30 numbers from four to six, and 30 numbers from seven to nine were selected from random.org/integers. Then, to randomize this list of 90 numbers, the part related to randomization of lists, website random.org/lists was used. In this way, the patients entering the study are assigned a random number that determines the relevant group. Numbers 1 to 3 are for the normal saline group (group A) and numbers 4 to 6 are grouped for the heparin group with a concentration of 30 units (group B) and numbers 7 to 9 are grouped for the heparin group with a concentration of 50 units (group C).

Patients are not aware of their treatment method. Based on the drug preparation protocol, the researcher prepares the studied solutions and codes them as A, B, C. The interventionist (patient-specific nurse), without knowing the identity of these codes, injects solution A to patient A, and in the same way, the rest of the codes are also injected to the patient corresponding to their code. The evaluator (patient-specific nurse) records the opening of the catheter with the corresponding specific code in the patient-specific form.