Comparison of the effect of vaginal cream of grape seed extract and clotrimazole on the treatment of candida vaginitis: a randomized clinical trial

Determining the comparative effect of grape seed extract vaginal cream and clotrimazole on the treatment of candidal vaginitis

A controlled, parallel-group, three-blind, randomized clinical trial on 70 patients with candidal vaginitis.

Women with vaginitis referred to women's clinics of hospitals affiliated to Ahvaz University of Medical Sciences. Then the women are examined and the symptoms are observed. Samples are taken from vaginal secretions and transferred to the laboratory, and after confirmation of candida vaginitis, clotrimazole cream or grape extract is given according to the group.

Inclusion criteria: consent to participate in the research, diagnosis of candidal vaginitis, not suffering from diabetes mellitus and diseases that weaken the immune system, not using broad-spectrum antibiotics in the last 2 weeks, not using vaginal douches in the last 48 hours, not using Vaginal drugs during the last week and also not using hormonal drugs during the last 3 months, not having iodine, not having candida infection more than 4 times a year. Non-entry criteria: vaginal bleeding, grape allergy, pregnancy and breastfeeding

In both groups (grape extract cream and clotrimazole cream), patients will be asked to use one applicator (5 grams) of the cream intravaginally for one week.

Duration of treatment, burning, itching, secretions

Sampling will be done by the available method, in such a way that married and non-pregnant women who refer to the women's clinic of Ahvaz University of Medical Sciences due to candidal vaginitis and are eligible to enter the study are selected. The research units will be assigned to two intervention and control groups using the random block method (six blocks). In this way, the 6 possible states of the blocks (AABB, ABAB, BBAA, BABA, ABBA, BAAB) will be listed first. And each block will be assigned a number from one to six. Then a number between one and six is randomly selected using the random number table, and then people are selected based on the block corresponding to the number. will be assigned to the intervention (A) and control (B) groups. This work will continue until the sample volume is completed.

Grape extract cream and Clotrimazole cream will be specified by the pharmacist with a code, and the researcher, research units and statistical analysts do not know the content of the creams according to A and B codes.

The reviewed data can be shared without mentioning the names of people

The access period starts 6 months after the results are published

Policymakers, researchers in academic and scientific institutions

If you have an official letter from the scientific center

Request from the printed magazine and indexed sites, request via e-mail of the project manager

6 months after completing the study of the application, the data will be sent to the project manager, if the conditions are met, up to two months.