Determining the effect of venous magnesium on improving the quality of anesthesia in patients undergoing appendectomy under spinal anesthesia

Determining the effect of venous magnesium on improving the quality of anesthesia in patients undergoing appendectomy under spinal anesthesia

Clinical trial with a control group, with parallel groups, double-blind, randomized, phase 0 on 84 patients. The randomization of patients into two groups will be in the form of blocks, and for the 84 studied patients, four blocks of different sequences A, B have been prepared with the help of statistical software.

This study will be conducted on 84 patients referred to Fatemi Ardabil Hospital with diagnosis of acute appendicitis. The present study is a double-blind clinical trial in which the patient and the evaluator are not aware of the intended intervention For patients in the intervention group, intravenous magnesium sulfate will be used, and in the control group, normal saline will be used as a placebo. Patients will be evaluated using a questionnaire

Entry requirements: age 18 to 50, acute appendicitis patients Conditions of non-entry: history of drug abuse, alcohol consumption, recent use of tranquilizers, sedatives and antipsychotics, antihypertensive drugs, calcium channel blockers, and the existence of neuromuscular diseases, thyroid disorders, kidney and heart disease

In this study, the patients of the study group were given magnesium sulfate in the amount of 50 mg per kilogram of body weight intravenously before the operation and 8 mg per kilogram during the operation, and the patients of the control group were given an equal volume of isotonic normal saline solution intravenously will receive.

Pain, nausea and vomiting, anxiety, satisfaction of the surgeon

After entering the study, patients are randomly assigned to two experimental groups (study intervention) and control based on codes A and B.The method of randomly assigning patients to two groups will be in the form of blocks, for the 84 patients studied previously, four blocks of different sequences A, B have been prepared with the help of statistical software, and the random sequences obtained in the form of envelopes containing codes A and B in the package are given to a person who does not know about the drugs used, and after each person enters the study, the corresponding envelope is opened and the person's code is determined, and the corresponding intervention is performed by the anesthesia resident who is not part of the study.

Patients and the operator will be unaware of the type of medicine.