The effect of Silymarin on the level of lipid profile and fasting blood sugar and HbA1c in patients with type 2 diabetes.

The effect of Silymarin supplementation on lipid profile and fasting blood sugar and HbA1c in patients with type 2 diabetes

A controlled, parallel-group, single-blind, randomized, phase II-III clinical trial in 48 patients. Using a block randomization approach.

The present study includes 48 adults with T2DM aged 30-68 years who referred to the Endocrinology and Metabolism Research Institute of Iran University of Medical Sciences in 2021.in intervention group three 140 mg pills per day were chosen as the supplementary dosage for Silymarin the control group were placed on a carbohydrate distribution diet for 12 weeks. The tablet was administered by an endocrinologist and the patient and the project's executor did not know that the supplement had received Silymarin, this study was a single-blind.

Age group 68-30 years Fasting plasma sugar more than 126 mg/dl Duration of the onset of the disease more than 2 years exclusion criteria؛ Cardiovascular disease, infectious diseases, kidney disease, thyroid disease Treatment with Silymarin 30 days before study - Taking chemical drugs and herbal supplements and nutritional supplements - Insulin therapy

In diabetes, Silymarin reduces plasma glucose by reducing insulin resistance and repairing beta cells in the pancreas. Each patient in the silymarin group was given 3 capsules of 140 mg silymarin daily and a carbohydrate distribution diet also the control group for 12 weeks

in both silymarin and control groups after the study, significant reduction was seen in lipid profile and glycemic index in both. However, after adjusted for physical activity, duration of diabetic, drug use no significant difference was observed between the two groups for other investigated factors after 12 weeks of intervention.

Simple randomization: Simple randomization is one of the most popular methods used to implement the randomization process. In this method, there is a possibility of inequality in the number of people assigned to each group, especially in studies with a small sample size.

First, the case of diabetic patients whose ages were between 30-68 years old was examined by visiting the clinic of the Endocrine Research Institute of Iran University of Medical Sciences and coordinating with the relevant officials. Then they were selected by simple non-probability sampling (convenience sampling). The objectives of this research were fully explained to the subjects. If they are willing to cooperate, they were asked to read and fill out a written consent form and register in the project. The researcher gave the two control and intervention groups a diet plan and Silymarin tablets were prescribed by a senior endocrinologist, and the nutritionist and the project manager did not know which person received Silymarin supplements.

Clinical study report-Study protocol Only part of the data, such as information related to the main outcome, can be shared.

The access period begins 6 months after the results are published.

Researchers working in academic and scientific institutions

Researchers can see the main result of the study, including the results and review of the study.

Phytotherapy Research Samira Ferdowsi

The data will be shared after publication in the journal.