The purpose of this study is determine the level of patient’s satisfaction of upper gastrointestinal endoscopy using EMLA cream, EMLA gel, Lidocaine gel, Lidocaine spray and placebo gel and comparison the satisfaction of various groups together. This study design is double-blind clinical trial, considered population includes patients who under upper gastrointestinal endoscopy in Hajar hospital of Shahrekord. The number of patients studied is 150, they are randomly divided into 5 groups of 30 people, including (A, B, C, D and E). The EMLA cream are used five minutes before the endoscopy for Group A, EMLA gel for Group B, Lidocaine gel for group C, Lidocaine spray 1% (3 puffs in posterior part of the tongue) for group D and placebo gel group E that the cream and gel dose is 5 g in posterior part of the tongue for each patient, then patients undergoing upper gastrointestinal endoscopy. Inclusion criteria: upper gastrointestinal endoscopy in these patients should be a non-emergency; no history of upper gastrointestinal endoscopy. Exclusion criteria: age under 12 years; patients with acute gastrointestinal bleeding. Then primary outcome include the satisfaction of patients of endoscopy and secondary outcome include the pain and discomfort in the throat and neck area, the incidence of nausea, vomiting or retching will be examined during and up to half an hour after endoscopy.