Effect of lavender oil on some clinical symptoms of patients with knee osteoarthritis referred to the rheumatology clinic : a double blind randomised control trial

Determining the effect of lavender oil on a number of clinical symptoms of knee osteoarthritis patients who referred to the rheumatology clinic of Ali Bin Abi Taleb Hospital in Rafsanjan in 2023

Clinical trial with control group and double-blind with simple randomization method, phase 3 on 105 patients.

A clinical trial will be conducted in 1401 on osteoarthritis patients referring to the rheumatology clinic of Rafsanjan city. Diagnosis is made by the American College of Rheumatology. The amount of pain, morning dryness, range of motion and performance of patients in all three intervention groups at the beginning and end of the study, with the help of (VAS) and (WOMAC). Double blind Clinical symptoms are assessed by a rheumatologist who is not aware of the type of medication used by each individual.

Age 45-70 years, the diagnosis of osteoarthritis of the knee is based on the diagnostic criteria of the ACR and the rheumatologist's diagnosis, existence of moderate pain in the knee during 24 hours based on the linear-visual scale of pain between 4-7 cm, Allergy to lavender Reluctance to continue participating in the study Non-compliance with the study protocol Observing any side effects caused by lavender in the patient's opinion

The participants are divided into three groups of 35 people A, B and C. In group A prepared paraffin oil without effect (placebo group), in group B lavender oil (intervention group) and in group C piroxicam gel (control group). The duration of the treatment is one month and the medicine is used topically once a day.

Pain and status of osteoarthritis in terms of morning stiffness, range of motion and function of patients

Patients are randomly divided into three groups of 35 people, A, B, and C, using a simple randomization method (random number table). In group A, prepared paraffin oil without effect (placebo group), in group B, topical lavender oil (intervention group) and in group C, piroxicam gel (control group).

In order to make the study double-blind, before the start of the study, the drugs are coded by someone other than the evaluator (secretary). Drug grouping and prescription is done by the rheumatology subspecialist in the form of drug A or B or C and drug delivery is done by another person (secretary). In addition, the analyzer is unaware of the grouping method and the drug used (double blind). In the placebo group, Paraffin oil, which is a ready-made pharmaceutical base without any effect, is used along with a color similar to lavender for placebo. The color of drug and placebo and the vials containing them are completely similar.