the effect of ventilator settings based on diaphragm thickening fraction on diaphragm atrophy

In this study, we are investigating the effect of ventilator settings based on diaphragm thickness fraction on diaphragm atrophy.

A parallel, double-blind, randomized controlled clinical trial on 40 critically ill poisoning patients admitted to the intensive care unit. The random sequence will be generated through randomization.com. Randomization will be done in blocks of 4

This study is carried out in ICUs of Imam Reza (AS) hospital. On 40 critically ill patients hospitalized in ICU who were intubated in the last 24 hours, in this study, in the intervention group, the ventilator was set to PCV mode. Settings are based on DTF. If the DTF is above 30%, the inspiratory pressure increases and if it is less than 15%, the inspiratory pressure decreases. The control group uses the usual ventilator settings. The researcher and the outcome evaluator do not know the group in which the patients are located. And the analyst does not know the group in which the patients are located.

Intubated patients: 1. Over 18 years old 2. Having informed consent (from the family) 3. Intubated in the last 24 hours. and be on PCV mode of ventilator 4. Absence of these diseases: lung disease, myopathy, brain disease, connective tissue disease 5. Absence of poisoning with things that cause muscle paralysis.

Intervention group: In the normal settings of the ventilator on PCVmode, the ventilator is set based on DTF. In this study, in the intervention group, diaphragm ultrasonography is performed every day and DTF is calculated, if the DTF is above 30%, in the same interval, the tidal volume is created at 6 to 8 cc/kg; Increased inspiratory pressure and if the DTF is less than 15%, in the same range; Inspiratory pressure decreases.

Diaphragm Atrophy

The Random allocation rule is the simplest method of limited randomization. This method represents a large block for the entire sample size, which means that the balance in the number of people allocated to each group will be achieved at the end of the study. For this purpose, the researchers first determined a total sample size (40 people) and then randomly assigned groups of them to group A and the rest to group B. For example, in a study with a sample size of 40 people, 20 balls for the intervention group A and 20 balls for the control group B are placed in a lottery container, and then the balls are randomly removed from the container without replacement and the created sequence is recorded. It should be noted that random sequence generation will be done through randomization.com Allocation Concealment: Sealed envelopes Randomization Unit: Individual

In this study, the researcher and the outcome evaluator do not know the group in which the patients are located. In this study, the data analyst does not know the group in which the patients are located.

Information about the outcomes of the study is published in a research paper

At the same time as the article is published

Researchers working in academic and scientific institutions

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