Investigating the effectiveness of beta-blockers on hypermetabolic response in adult patients referred to hospital due to acute burns: a single-blind randomized clinical trial

Inclusion criteria:

Having wounds from 20 to 50% of the total body surface Consent to participate in data collection From the age of 18 to the age of 65 and of both sexes A history of acute burns in the last two days

Exclusion criteria:

Medical conditions against propranolol use Head injury History of cardiopulmonary endocrine and peripheral diseases Systolic blood pressure less than 90 Heart rate less than 60 Inhalation damage History of malignancy History of AIDS Complexes related to AIDS and HIV History of IMI (less than the last 6 weeks), tuberculosis, arthritis, cirrhosis, hyperlipidemia, bone or endocrine diseases, autoimmune diseases Long-term use of corticosteroids or non-steroidal anti-inflammatory drugs Renal failure defined as creatinine greater than 3 Liver disease defined as bilirubin more than 3 Anoxic brain damage Patients with asthma and a history of airway narrowing Respiratory burn History of joint or bone disease Peripheral or central nerve damage Diabetes or taking any medication that affects the autonomic system Any type of plastering Skin wound or skin graft Contraindication to the use of propranolol Hypersensitivity to propranolol A history of hyperthyroidism, unless you are using Synthroid or other thyroid hormones Chronic opioid overdose pre-burn Receiving propranolol in the past 6 months Multiple severe allergic reactions Daily use of methylphenidate or similar stimulants Presence of hypoxic brain injury that is not expected to lead to full recovery History of chronic obstructive pulmonary disease and history of medication use including blocking agents (alpha and beta) or other antiarrhythmic drugs and medical conditions requiring glucocorticoid therapy prior to burn injury.

Target sample size: 90