Comparison of the effect of perioperative intravenous ketamine with fentanyl in control of acute pain after inguinal hernia repair surgery

Comparison of the effect of perioperative intravenous ketamine with fentanyl in control of acute pain after inguinal hernia repair surgery

A randomized, double-blind clinical trial with a parallel groups design; phase 1-2; on 60 patients; divided into two groups of ketamine and fentanyl (control) by random software allocation.

This study will be conducted in urmia Imam Khomeini Medical Center. After entering the study, the participants will be randomly assigned to one of two ketamine and fentanyl (control) groups with 30 participants in each group. The patients and the nurse who will take care of them during the procedure will be blinded.

Inclusion criteria: 30-60 aged adults with inguinal hernia, Absence of contraindications for ketamine and opioids use, patients with American Society of Anesthesiologist (ASA) physical status I,II Exclusion criteria: History of allergic reactions to the drug under study, History of underlying diseases (diabetes, peptic ulcer, gastritis, coronary artery disease, renal failure), Any known psychiatric disorder, Patients with incarcerated hernia, patients with severe infection

Intervention group: In ketamine group, Induction of anesthesia is done with 1 to 4 mg/kg of intravenous ketamine, and then in maintenance phase, intravenous perfusion of ketamine at a rate of 2 to 10 μg/kg/min will be prescribed. Control group: In fentanyl group, induction of anesthesia is performed with 1-2 μg/kg fentanyl as a routine anesthetic drug, and then maintenance phase, continuous infusion of fentanyl at a rate of 1-2 μg/kg/hr will be prescribed.

Postoperative pain measurement at 60, 90 minutes and 24 hours after surgery with numeric rating (NRS) scale from 0 to 10

Patients are randomly assigned to two ketamine and fentanyl (control) groups using Random Allocation computer software. In this way, numbers are given to the patients according to the determined sample volume, and then the software allocates the patients to two ketamine and fentanyl (control) groups based on the given numbers.

After introducing the study to the patients and explaining the benefits and harms of the possible intervention, written consent is obtained from the patients. Then the patients are randomly assigned to one of the intervention or control groups. Patients and nurses who take care of the patients during the trial are blinded to the intervention and control groups, so that none of the nurses and patients know which drug, ketamine or fentanyl, the patients have been under general anesthesia with.