Effects of anti-inflammatory diet on inflammatory biomarkers, gut microbiome and disease severity in clinically-diagnosed women with depression

Determining the effect of anti-inflammatory diet on some inflammatory indicators, gut microbiome composition, and symptoms and disease severity in patients with depression.

A clinical trial with a control group, with two parallel groups, without blinding, randomized, and on 60 patients who were randomly assigned in a pot.

Intervention in the hospital and in parallel and without blinding

1. Taking antibiotics 2. Taking probiotic supplements 3. Vigorous physical activity 4. Changing the type or dose of medication used for mental disorders 5. Hospitalization due to severe depression 6. Getting pregnant 7. Smoking 8. Getting infected with the coronavirus 9. The occurrence of unpleasant events such as the death of loved ones or close relatives 10. Body mass index more than 35 or less than 20 kg/m2.

the intervention group in this study will receive an anti-inflammatory diet. first, using the age, sex, height, and current weight of the patients in the Harris-Benedict formula, the basal metabolic rate (BMR) of the patients will be calculated. Then the daily energy requirement of each person is calculated based on his physical activity and taking into account the thermogenic effect of food (TEF), then based on the person's current BMI, the energy intake of overweight and obese people is limited to 500 calories. will be done. The food plan of these people will be adjusted in such a way that macronutrients will be distributed as follows: carbohydrates 50-55% of energy, fat 25-30% of energy, and protein 15-20% of energy. Based on this division, the required amounts of each food group will be calculated. People in the control group will receive their usual dietary intake for 8 weeks

Inflammatory biomarkers, gut microbiome, and severity of depression

People will be placed in blocks of two according to their age (20 to 40 and 40 to 60 years) and body mass index (20 to 25, 25 to 30 and 30 kg/m2 and above). Then, the people placed in each two-person block will be randomly assigned to intervention and non-intervention groups. To randomly assign people to groups, each person is assigned a code and these codes are poured into a pot. A person outside the study is then asked to draw codes from the pot using a lottery. The first code will be assigned to the intervention group, the second code will be assigned to the control group, and the rest of the people will be randomly assigned to two groups.